CFLAR information

CFLAR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3H11, 3H13, 2N5R
Identifiers
Aliases	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
External IDs	OMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,176,687 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,798,043 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; left ventricle; ; blood; ; gastrocnemius muscle; ; bone marrow cells; ; monocyte; ; renal medulla; ; spleen; ; lymph node;
	Top expressed in
	ascending aorta; ; aortic valve; ; proximal tubule; ; right lung; ; right lung lobe; ; ciliary body; ; thymus; ; lateral recess; ; retinal pigment epithelium; ; left lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; protein binding; cysteine-type endopeptidase activity involved in execution phase of apoptosis; enzyme activator activity; cysteine-type endopeptidase activity; peptidase activator activity; protein heterodimerization activity; protease binding; death receptor binding; protein-containing complex binding; cysteine-type endopeptidase activity involved in apoptotic process;
Cellular component	cytosol; CD95 death-inducing signaling complex; ripoptosome; death-inducing signaling complex; membrane raft; cytoplasm;
Biological process	regulation of apoptotic process; execution phase of apoptosis; negative regulation of apoptotic process; proteolysis; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of necroptotic process; regulation of extrinsic apoptotic signaling pathway via death domain receptors; viral process; apoptotic process; positive regulation of catalytic activity; response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; positive regulation of neuron projection development; cellular response to insulin stimulus; response to testosterone; positive regulation of ERK1 and ERK2 cascade; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to hypoxia; cellular response to dexamethasone stimulus; cellular response to nitric oxide; positive regulation of glomerular mesangial cell proliferation; positive regulation of extracellular matrix organization; negative regulation of reactive oxygen species biosynthetic process; negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of hepatocyte apoptotic process; negative regulation of epithelial cell apoptotic process; positive regulation of hepatocyte proliferation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; skeletal muscle tissue development; positive regulation of peptidase activity; skeletal muscle atrophy; regulation of skeletal muscle satellite cell proliferation; skeletal myofibril assembly; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; skeletal muscle tissue regeneration; positive regulation of NF-kappaB transcription factor activity; negative regulation of necroptotic process; negative regulation of myoblast fusion; negative regulation of extrinsic apoptotic signaling pathway; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	8837
	12633
	ENSG00000003402
	ENSMUSG00000026031
	O15519
	O35732
NM_001127183; NM_001127184; NM_001202515; NM_001202516; NM_001202517;
	NM_001202518; NM_001202519; NM_001308042; NM_001308043; NM_003879; NM_001351590; NM_001351591; NM_001351592; NM_001351593; NM_001351594
NM_001289704; NM_001293804; NM_001293805; NM_009805; NM_207653;
	NM_001355056
NP_001120655; NP_001120656; NP_001189444; NP_001189445; NP_001189446;
	NP_001189447; NP_001189448; NP_001294971; NP_001294972; NP_003870; NP_001338519; NP_001338520; NP_001338521; NP_001338522; NP_001338523
NP_001276633; NP_001280733; NP_001280734; NP_033935; NP_997536;
	NP_001341985
	Wikidata
View/Edit Human	View/Edit Mouse

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[5]^[6] Also called c-FLIP (FLICE-like inhibitory protein).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000003402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026031 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
^ Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP" (PDF). Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161. S2CID 4341495.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000003402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026031 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9208847-5] Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.

[pmid9217161-6] Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP" (PDF). Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161. S2CID 4341495.

CFLAR information

and 13 Related for: CFLAR information

CFLAR

Flip

Catalytic triad

Pseudoprotease

Fas receptor

P53

Caspase 3

Caspase 8

DEDD

RIPK1

Caspase 10

TRAF1

TRAF2