Comparison of Azurocidin 1 structure (pseudoprotease) to Chymotrypsin (functional protease) of same superfamily
Pseudoproteases are catalytically-deficient pseudoenzyme variants of proteases that are represented across the kingdoms of life.[1][2]
^Fischer, Katja; Reynolds, Simone L. (2015-05-15). "Pseudoproteases: mechanisms and function". Biochemical Journal. 468 (1): 17–24. doi:10.1042/BJ20141506. ISSN 1470-8728. PMID 25940733.
^Todd AE, Orengo CA, Thornton JM (October 2002). "Sequence and structural differences between enzyme and nonenzyme homologs". Structure. 10 (10): 1435–51. doi:10.1016/s0969-2126(02)00861-4. PMID 12377129.
Pseudoproteases are catalytically-deficient pseudoenzyme variants of proteases that are represented across the kingdoms of life. Protease Pseudoenzyme...
cellular signalling functions are probably the pseudokinases, the pseudoproteases and the pseudophosphatases. Recently, the pseudo-deubiquitylases have...
C, Strisovsky K, Lastun V, Freeman M (Apr 2011). "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling"...
Strisovsky K, Lastun V, Freeman M (April 2011). "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling"...
for proteolysis, implying that they cannot cleave substrates. These ‘pseudoproteases’ include a subfamily that have been named the iRhoms (also known as...
Global Information