Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is mostly associated with, but not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (γδ) Τ cells and activated CD8+ T cells, as well as on dendritic cells.[5] NCAM has been implicated as having a role in cell–cell adhesion,[6] neurite outgrowth, synaptic plasticity, and learning and memory.
^ abcGRCh38: Ensembl release 89: ENSG00000149294 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000039542 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Van Acker HH, Capsomidis A, Smits EL, Van Tendeloo VF (2017). "CD56 in the Immune System: More Than a Marker for Cytotoxicity?". Frontiers in Immunology. 8: 892. doi:10.3389/fimmu.2017.00892. PMC 5522883. PMID 28791027.
^Pathology Outlines
and 27 Related for: Neural cell adhesion molecule information
Neuralcelladhesionmolecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle...
Celladhesionmolecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular...
Celladhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process...
and his team went on to isolate the first neuralcell-adhesionmolecule (N-CAM), one of the many molecules that hold the animal nervous system together...
examples of this are neuralcelladhesionmolecule (NCAM) and blood proteins where fine details in the carbohydrate structure determine cell binding (or not)...
Schwann cells. Schwann cell migration is regulated by integrins with ECM molecules such as fibronectin and laminin. In addition, neuralcelladhesion molecule...
Neuralcelladhesionmolecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene. CHL1 is...
myosin. This prevents the development of multiple axons. The neuralcelladhesionmolecule N-CAM simultaneously combines with another N-CAM and a fibroblast...
future vitreous humor). Neuralcelladhesionmolecule (N-CAM) will mediate this attachment via homophilic interactions between molecules of like isoforms (A...
similar to those of the neuralcelladhesionmolecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherens junctions...
some molecules of this family: NCAMs NeuralCellAdhesionMolecules ICAM-1 Intercellular CellAdhesionMolecule VCAM-1 Vascular CellAdhesionMolecule PECAM-1...
same adhesionmolecule can sort out. The molecules responsible for adhesion are called celladhesionmolecules (CAMs). Several types of celladhesion molecules...
hydrophilic molecules. As such they are unable to diffuse freely across the bi-lipid layer of the plasma membrane, so their action is mediated by a cell membrane...
by their expression of the cell surface molecule, a polysialylated (PSA) embryonic form of the neuralcelladhesionmolecule (NCAM) called PSA-NCAM, as...
1999). "Polysialylated neuralcelladhesionmolecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after...
serotonin, neurofilament and Neural cell adhesionmolecule; they are S-100 protein negative. The sustentacular cells are S-100 positive and focally positive...
activated human satellite cells can be identified by the membrane-bound neuralcelladhesionmolecule (N-CAM/CD56/Leu-19), a cell-surface glycoprotein. Myocyte...
functionality, adhesions and adhesionmolecules have been a topic of study within the scientific community. Specifically, it has been found that adhesions are involved...
presumptive neural crest cells are initially anchored to neighboring cells by tight junction proteins such as occludin and celladhesionmolecules such as...
In regenerating neuralcells, neurite promoting factors play a role in adhesion of the axon and include neuralcelladhesionmolecule (N-CAM) and N-cadherin...
polysialic acid, a modulator of the adhesive properties of neuralcelladhesionmolecule (NCAM1). The encoded protein, which is a member of glycosyltransferase...
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