Prolonged recovery from paralysis in self or blood relative
Prevention
Alternative neuromuscular blockade agents, cocaine avoidance
Treatment
Mechanical ventilation
Frequency
1:2000-4000 General Population
Pseudocholinesterase deficiency is an autosomal recessive inherited blood plasma enzyme abnormality in which the body's production of butyrylcholinesterase (BCHE; pseudocholinesterase aka PCE) is impaired. People who have this abnormality may be sensitive to certain anesthetic drugs, including the muscle relaxants succinylcholine and mivacurium as well as other ester local anesthetics.[1]
^Maiorana, A; Roach Jr, RB (2003). "Heterozygous pseudocholinesterase deficiency: A case report and review of the literature". Journal of Oral and Maxillofacial Surgery. 61 (7): 845–7. doi:10.1016/S0278-2391(03)00163-0. PMID 12856264.
and 18 Related for: Pseudocholinesterase deficiency information
Pseudocholinesterasedeficiency is an autosomal recessive inherited blood plasma enzyme abnormality in which the body's production of butyrylcholinesterase...
disability if the disease is untreated. Another example is pseudocholinesterasedeficiency, in which the body's ability to break down choline ester drugs...
Butyrylcholinesterase may be a physiological ghrelin regulator. Pseudocholinesterasedeficiency results in delayed metabolism of only a few compounds of clinical...
of the anaesthetic succinylcholine are often diagnosed with Pseudocholinesterasedeficiency which is a clinically silent condition in individuals who are...
discover genetic disorders (such as malignant hyperthermia or pseudocholinesterasedeficiency), habits (tobacco, drug and alcohol use), physical attributes...
condition known as pseudocholinesterasedeficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle...
combinations with the Eu gene, or other atypical genes (see Pseudocholinesterasedeficiency). Such genes will result in a longer duration of action of...
individuals, it has a prolonged duration of action in patients with pseudocholinesterasedeficiency and it causes an increase in plasma potassium concentration...
syndromes; efficiency of local anesthetics can be reduced Pseudocholinesterasedeficiency Intra-articular infusion (this is not an approved indication...
specifically hookworm infection. His next major work was the case of pseudocholinesterasedeficiency, a deadly blood disease in which individuals have severe sensitivity...
an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is...
parent compound is rapid. There are concerns that those with pseudocholinesterasedeficiencies may have an increased sensitivity to benzonatate as this hydrolysis...
apnea during suxamethonium anesthesia could be attributed to a pseudocholinesterasedeficiency genoytpe. This discovery led him to propose the concept of...
succinylcholine administration may be due to butyrylcholinesterase (pseudocholinesterase) deficiency and may require prolonged mechanical ventilation. Unlike non-depolarizing...
genetic variants in patients who lacked butyrylcholinesterase ('pseudocholinesterase') following succinylcholine injection during anesthesia were first...
to P450 interactions. Inheriting abnormal butyrylcholinesterase (pseudocholinesterase) may affect metabolism of drugs such as succinylcholine. Inheriting...
cholinesterase test: a test of liver enzymes (acetylcholinesterase and pseudocholinesterase) useful as a test of liver function and to assess the effects of...
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