Procainamide (PCA) is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias. It is a sodium channel blocker of cardiomyocytes; thus it is classified by the Vaughan Williams classification system as class Ia. In addition to blocking the INa current, it inhibits the IKr rectifier K+ current.[1] Procainamide is also known to induce a voltage-dependent open channel block on the batrachotoxin (BTX)-activated sodium channels in cardiomyocytes.[2]
^Osadchii OE (August 2014). "Procainamide and lidocaine produce dissimilar changes in ventricular repolarization and arrhythmogenicity in guinea-pig". Fundamental & Clinical Pharmacology. 28 (4): 382–393. doi:10.1111/fcp.12046. PMID 23952942. S2CID 5086017.
^Zamponi GW, Sui X, Codding PW, French RJ (December 1993). "Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation". Biophysical Journal. 65 (6): 2324–2334. Bibcode:1993BpJ....65.2324Z. doi:10.1016/S0006-3495(93)81291-8. PMC 1225974. PMID 8312472.
Procainamide (PCA) is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias. It is a sodium channel blocker of cardiomyocytes;...
tachycardias. Oral procainamide is no longer being manufactured in the US, but intravenous formulations are still available. While procainamide and quinidine...
it is the N-acetylated metabolite of procainamide. It is a Class III antiarrhythmic agent, whereas procainamide is a Class Ia antiarrhythmic drug. It...
normal blood pressure and strong pulse, the antiarrhythmic medication procainamide may be used. Otherwise, immediate cardioversion is recommended, preferably...
an initial loading dose include digoxin, teicoplanin, voriconazole, procainamide and fulvestrant. One or series of doses that may be given at the onset...
pathway for metabolism, the drug candidate may have a longer half-life. Procainamide, an amide, has a longer duration of action than Procaine, an ester, because...
amiodarone may be used. A recent study suggested that another antiarrhythmic, procainamide, may be more effective in stopping ventricular tachycardia – with less...
blockers Diltiazem Verapamil Class IA antiarrhythmics such as Quinidine Procainamide Disopyramide Class IC antiarrhythmics such as Flecainide Isovoacangine...
depolarization in the ventricles and increases the absolute refractory period. Procainamide, quinidine and disopyramide are Class Ia agents. Class 1b drugs lengthen...
Personal Care Assistant, also known as unlicensed assistive personnel Procainamide EU-Armenia Partnership and Cooperation Agreement (PCA agreement between...
ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine. Cardiopulmonary bypass is used if symptoms are refractory...
injections) Concurrent treatment with quinidine, flecainide, disopyramide, procainamide (class I antiarrhythmic agents) Prior use of amiodarone hydrochloride...
heart rate may include beta blockers, or antiarrhythmic agents such as procainamide, which attempt to restore a normal heart rhythm. This latter group may...
Lichen planus (LP) is a chronic inflammatory and autoimmune disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen...
Beck used internal paddles on either side of the heart, along with procainamide, an antiarrhythmic drug, and achieved return of a perfusing cardiac rhythm...
(e.g. procaine or cocaine) -cain- for class I antiarrhythmics (e.g. procainamide) -coxib for COX-2 inhibitors, a type of anti-inflammatory drugs (e.g...
Global Information
