Bufexamac information

Bufexamac
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Topical, rectal
ATC code	M01AB17 (WHO) M02AA09 (WHO);
Legal status
Legal status	In general: Over-the-counter (OTC);
Pharmacokinetic data
Excretion	Renal
Identifiers
	IUPAC name 2-(4-butoxyphenyl)-N-hydroxyacetamide;
CAS Number	2438-72-4;
PubChem CID	2466;
IUPHAR/BPS	7498;
ChemSpider	2372;
UNII	4T3C38J78L;
KEGG	D01271;
ChEMBL	ChEMBL94394;
CompTox Dashboard (EPA)	DTXSID7045368 ;
ECHA InfoCard	100.017.683
Chemical and physical data
Formula	C12H17NO3
Molar mass	223.272 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ONC(=O)Cc1ccc(OCCCC)cc1;
	InChI InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14); Key:MXJWRABVEGLYDG-UHFFFAOYSA-N;

Bufexamac is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm and Parfenac. It was withdrawn in Europe and Australia^[1] because of allergic reactions.

^ "Bufexamac Safety advisory - risk of serious skin reactions". Therapeutic Goods Administration (TGA). 2020.

[1] "Bufexamac Safety advisory - risk of serious skin reactions". Therapeutic Goods Administration (TGA). 2020.

Bufexamac information

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Bufexamac

Analgesic

Salicylic acid

Prostaglandin

ATC code M02

Paracetamol

Naproxen

Selenium

Ketorolac

Resveratrol

Phenacetin

Carprofen

Acetanilide

Etoricoxib

Celecoxib

Nimesulide

Methyl salicylate

C12H17NO3

Curcumin

Aspirin

ATC code M01

Indometacin

Ricinoleic acid

Cyclooxygenase

Dexketoprofen

Retinoid

Loxoprofen

Piroxicam

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Topical, rectal
ATC code	M01AB17 (WHO) M02AA09 (WHO)
Legal status
Legal status	In general: Over-the-counter (OTC)
Pharmacokinetic data
Excretion	Renal
Identifiers
IUPAC name 2-(4-butoxyphenyl)-N-hydroxyacetamide
CAS Number	2438-72-4
PubChem CID	2466
IUPHAR/BPS	7498
ChemSpider	2372
UNII	4T3C38J78L
KEGG	D01271
ChEMBL	ChEMBL94394
CompTox Dashboard (EPA)	DTXSID7045368
ECHA InfoCard	100.017.683
Chemical and physical data
Formula	C₁₂H₁₇NO₃
Molar mass	223.272 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES ONC(=O)Cc1ccc(OCCCC)cc1
InChI InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14) Key:MXJWRABVEGLYDG-UHFFFAOYSA-N