Brincidofovir, sold under the brand name Tembexa, is an antiviral drug used to treat smallpox. Brincidofovir is a prodrug of cidofovir.[4] Conjugated to a lipid, the compound is designed to release cidofovir intracellularly, allowing for higher intracellular and lower plasma concentrations of cidofovir, effectively increasing its activity against dsDNA viruses, as well as oral bioavailability.[5]
The most common side effects include diarrhea, nausea, vomiting, and abdominal pain.[3] It carries an FDA-mandated black box warning of an increased risk of death with extended use.[6][7]
Brincidofovir was approved for medical use in the United States in June 2021.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"Regulatory Decision Summary for Tembexa". Drug and Health Products Portal. 11 December 2023. Retrieved 2 April 2024.
^ ab"FDA approves drug to treat smallpox". U.S. Food and Drug Administration (FDA). 4 June 2021. Archived from the original on 8 June 2021. Retrieved 7 June 2021. This article incorporates text from this source, which is in the public domain.
^Cite error: The named reference Chimerix was invoked but never defined (see the help page).
^Florescu DF, Keck MA (October 2014). "Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses". Expert Review of Anti-Infective Therapy. 12 (10): 1171–1178. doi:10.1586/14787210.2014.948847. PMID 25120093. S2CID 25854860.
^"FDA Tembexa Product Insert" (PDF).
^"DailyMed - TEMBEXA- brincidofovir tablet, film coated". dailymed.nlm.nih.gov.
Brincidofovir, sold under the brand name Tembexa, is an antiviral drug used to treat smallpox. Brincidofovir is a prodrug of cidofovir. Conjugated to a...
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but no proven, effective therapy is known in humans. For example, Brincidofovir (1-O-hexadecyloxypropyl-cidofovir /CMX001) available as Tembexa, suppresses...
military and maintained in the Strategic National Stockpile. In June 2021, brincidofovir was approved for medical use in the United States for the treatment...
basis in the event of a bioterror incident involving smallpox cases. Brincidofovir, a cidofovir derivative with much higher activity against smallpox that...
determine its safety and effectiveness in humans. Another example is brincidofovir. In June 2021, the FDA approved this drug for the treatment of smallpox...
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significant risks from tecovirimat and low certainty evidence that suggests brincidofovir may cause mild liver injury. Pain is common and may be severe; supportive...
significant risks from tecovirimat and low certainty evidence that suggests brincidofovir may cause mild liver injury. Pain is common and may be severe; supportive...
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This article incorporates text from this source, which is in the public domain.
