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Favipiravir information


Favipiravir
Clinical data
Trade namesAvigan (アビガン, Abigan), Avifavir,[1] Areplivir,[2] others
Other namesT-705, favipira, favilavir
Routes of
administration
By mouth
ATC code
  • J05AX27 (WHO)
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
IUPAC name
  • 6-fluoro-3-hydroxypyrazine-2-carboxamide
CAS Number
  • 259793-96-9
PubChem CID
  • 492405
DrugBank
  • DB12466
ChemSpider
  • 431002
UNII
  • EW5GL2X7E0
KEGG
  • D09537
ChEBI
  • CHEBI:134722
ChEMBL
  • ChEMBL221722
CompTox Dashboard (EPA)
  • DTXSID60948878 Edit this at Wikidata
Chemical and physical data
FormulaC5H4FN3O2
Molar mass157.104 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • C1=C(N=C(C(=O)N1)C(=O)N)F
InChI
  • InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)
  • Key:ZCGNOVWYSGBHAU-UHFFFAOYSA-N

Favipiravir, sold under the brand name Avigan among others,[3] is an antiviral medication used to treat influenza in Japan.[4] It is also being studied to treat a number of other viral infections, including SARS-CoV-2.[4] Like the experimental antiviral drugs T-1105 and T-1106, it is a pyrazinecarboxamide derivative.[5]

It is being developed and manufactured by Toyama Chemical (a subsidiary of Fujifilm) and was approved for medical use in Japan in 2014.[6] In 2016, Fujifilm licensed it to Zhejiang Hisun Pharmaceutical Co.[7] It became a generic drug in 2019.[citation needed]

  1. ^ Cite error: The named reference Avifavir was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Areplivir was invoked but never defined (see the help page).
  3. ^ "Glenmark launches Covid-19 drug FabiFlu, priced at Rs 103 per tablet". Business Standard India. Press Trust of India. 20 June 2020.
  4. ^ a b Du YX, Chen XP (August 2020). "Favipiravir: Pharmacokinetics and Concerns About Clinical Trials for 2019-nCoV Infection". Clinical Pharmacology and Therapeutics. 108 (2): 242–247. doi:10.1002/cpt.1844. PMID 32246834.
  5. ^ Furuta Y, Takahashi K, Shiraki K, Sakamoto K, Smee DF, Barnard DL, et al. (June 2009). "T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections". Antiviral Research. 82 (3): 95–102. doi:10.1016/j.antiviral.2009.02.198. PMC 7127082. PMID 19428599.
  6. ^ Cite error: The named reference Shi2020 was invoked but never defined (see the help page).
  7. ^ EJ Lane (22 June 2016). "Fujifilm in Avigan API license with Zhejiang Hisun Pharmaceuticals". Fierce Pharma. Retrieved 20 April 2020.

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