Biotin synthase (BioB) (EC 2.8.1.6) is an enzyme that catalyzes the conversion of dethiobiotin (DTB) to biotin; this is the final step in the biotin biosynthetic pathway. Biotin, also known as vitamin B7, is a cofactor used in carboxylation, decarboxylation, and transcarboxylation reactions in many organisms including humans.[1] Biotin synthase is an S-Adenosylmethionine (SAM) dependent enzyme that employs a radical mechanism to thiolate dethiobiotin, thus converting it to biotin.
This radical SAM enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is dethiobiotin:sulfur sulfurtransferase. This enzyme participates in biotin metabolism. It employs one cofactor, iron-sulfur.
^Roth KS (September 1981). "Biotin in clinical medicine--a review". The American Journal of Clinical Nutrition. 34 (9): 1967–74. doi:10.1093/ajcn/34.9.1967. PMID 6116428.
Biotinsynthase (BioB) (EC 2.8.1.6) is an enzyme that catalyzes the conversion of dethiobiotin (DTB) to biotin; this is the final step in the biotin biosynthetic...
Biotin (also known as vitamin B7 or vitamin H) is one of the B vitamins. It is involved in a wide range of metabolic processes, both in humans and in other...
(ADP-forming). This enzyme is also called desthiobiotin synthase. This enzyme participates in biotin metabolism. As of late 2007, 14 structures have been...
commonly recognized by name than by number, such as pantothenic acid (B5), biotin (B7), and folate (B9). B vitamins are present in protein-rich foods, such...
are independently responsible for biotin synthesis and lipoic acid metabolism, respectively. BioB or biotinsynthase is a radical SAM enzyme that employs...
lipid A biosynthesis. 8-amino-7-oxononanoate synthase catalyzes the first committed step in plant biotin synthesis. MurA catalyzes the first committed...
in the large subunit of CPSase is also present as a single copy in the biotin-dependent enzymes acetyl-CoA carboxylase (ACC), propionyl-CoA carboxylase...
oxaloacetate from pyruvate. The enzyme is a mitochondrial protein containing a biotin prosthetic group, requiring magnesium or manganese and acetyl-CoA. Pyruvate...
inhibited by UTP (Uridine triphosphate) Neither CPSI nor CPSII require biotin as a coenzyme, as seen with most carboxylation reactions. It is one of the...
adenylyltransferase and archaeal FAD synthase, whereas the class II aaRSs have a unique fold related to biotin and lipoate ligases. The alpha helical...
Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. pp. 87–122....
in 2013 by mating cultures in the dark on oatmeal agar supplemented with biotin, after the mating types (MAT1-1 or MAT1-2) of the strains had been determined...
tetrahydrothiophene-ring containing antibiotics from streptomyces while biotin and neothiobinupharidine (and other nuphar alkaloids ), are examples of...
of lipoic acid or pantothenic acid reduces the uptake of biotin and/or the activities of biotin-dependent enzymes. Lipoic acid is a cofactor for at least...
Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. pp. 150–195...
classified according to the cofactors that catalyze the transformations. Biotin-coupled processes effect the decarboxylation of malonyl-CoA to acetyl-CoA...
Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. pp. 58–86....
As a result, niacin can become deficient and require supplementation. Biotin can be provided in feline diets by adding cooked eggs, liver, milk, legumes...
which is used in the synthesis of acetyl-CoA and other compounds. During biotin deficiency, HMB can be synthesized from MC-CoA via enoyl-CoA hydratase and...
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