Berberine reductase (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction
(R)-canadine + 2 NADP+ berberine + 2 NADPH + H+
Thus, the two substrates of this enzyme are (R)-canadine and nicotinamide adenine dinucleotide phosphate ion, whereas its 3 products are berberine, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-tetrahydroberberine:NADP+ oxidoreductase. This enzyme is also called (R)-canadine synthase.
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Berberinereductase (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction (R)-canadine + 2 NADP+ ⇌ {\displaystyle \rightleftharpoons } berberine...
Risarestat, Sorbinil, and Berberine, Poliumoside, Ganoderic acid are currently in clinical trials. AKR1B1 Aldo-keto reductase Petrash JM (April 2004)....
inhibited 5α-reductase in the skin in this region by 75%. In addition to inhibition of 5α-reductase, progesterone is metabolized by 5α-reductase into 5α-dihydroprogesterone...
Jaggi AS (March 2014). "Alkaloids as aldose reductase inhibitors, with special reference to berberine". Journal of Alternative and Complementary Medicine...
the 5α-reductase inhibitor dutasteride resulted in only slightly higher progesterone levels with transdermal progesterone. Finally, 5α-reductase is also...
which make them suitable candidates for delivery by serum proteins. Berberine Jatrorrhizine Phellodendrine Yang, Seong Baek; Kim, Eun Hee; Kim, Seung...
NADPH-dependent reductase enzymes, which have been characterized in multiple plant species. These plant species all contain two types of the reductase enzymes...
prevalences, degrees of association and strength of effect on type 2 diabetes. Berberine, an isoquinoline alkaloid, has been shown to increase adiponectin expression...
is known that lamotrigine is a weak inhibitor of human dihydrofolate reductase (DHFR) and other, more powerful, human DHFR inhibitors such as methotrexate...
then produce testosterone, which is converted to DHT via the enzyme 5α-reductase. DHT is a potent androgen that is responsible for the masculinization...
Bespalov M, Hanski L, Wennerberg K, et al. (February 2016). "Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other...
inhibitors directly inhibit the enzymatic biosynthesis of steroids. HMG-CoA reductase (HMGCR) inhibitors, also known as statins, prevent the conversion of HMG-CoATooltip...
Subsequently, testosterone can be metabolized into dihydrotestosterone by 5α-reductase. In addition, androstenedione and testosterone can be converted into estrone...
compounds, including epigallocatechin gallate (EGCG), caffeine, curcumin, berberine, quercetin, resveratrol and pterostilbene, have been reported to inhibit...
resulting in (B), which enzymes chalcone synthase (CHS) and chalcone reductase (CHR) modify to obtain trihydroxychalcone. CHR is NADPH dependent. Chalcone...
obstruction of Z-ring formation by SulA and other FtsZ inhibitors (e.g. berberine) induces filamentation too. Some protein synthesis inhibitors (e.g. kanamycin)...
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