Ribbon diagram of human aldose reductase in complex with NADP+, citrate, and IDD594, a small molecule inhibitor. From PDB: 1us0.
Identifiers
EC no.
1.1.1.21
CAS no.
9028-31-3
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In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism.[1]
^Petrash JM (April 2004). "All in the family: aldose reductase and closely related aldo-keto reductases". Cell. Mol. Life Sci. 61 (7–8): 737–49. doi:10.1007/s00018-003-3402-3. PMC 11138595. PMID 15094999. S2CID 25983505.
In enzymology, aldosereductase (or aldehyde reductase) (EC 1.1.1.21) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a...
Aldosereductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. Their target, aldose...
subsequently oxidized to fructose. It is also called the sorbitol-aldosereductase pathway. The pathway is implicated in diabetic complications, especially...
into a hydroxyl group. The reaction requires NADH and is catalyzed by aldosereductase. Glucose reduction is the first step of the polyol pathway of glucose...
Aldo-keto reductase family 1, member B1 (AKR1B1), also known as aldosereductase, is an enzyme that is encoded by the AKR1B1 gene in humans. It is a reduced...
is a carboxylic acid derivative and a noncompetitive and reversible aldosereductase inhibitor used for the treatment of diabetic neuropathy, which is one...
lisinopril, and Merck received the exclusive rights to an earlier stage aldosereductase inhibitor drug candidate, a potential treatment for diabetes. Zeneca's...
strongly conserved, this is evidence of abnormal kidney function. Aldosereductase inhibitor Alpha cell one of the types of cell in the pancreas (in areas...
human aldosereductase through a bromine halogen bond, as shown in the figure. The molecules fail to bind to each other if similar aldehyde reductase replaces...
Galactitol is produced from galactose in a reaction catalyzed by aldosereductase. The other common galactose metabolism defect is a defect in galactose-1-phosphate...
However, galactose concentration must be fairly high before the enzyme, aldosereductase, will convert significant amounts of the sugar to its galactitol form...
is the reduction of aldoses, types of sugars including galactose, to sugar alcohols. Recent data suggests that aldosereductase is the enzyme responsible...
Ranirestat (also known as AS-3201) is an aldosereductase inhibitor being developed for the treatment of diabetic neuropathy by Dainippon Sumitomo Pharma...
Dahlia, Butea (Butea monosperma) and Coreopsis. It has antioxidative, aldosereductase and advanced glycation endproducts inhibitory effects. It is also a...
evidence is of low to moderate quality. A 2007 Cochrane review of aldosereductase inhibitors for the treatment of the pain deriving from diabetic polyneuropathy...
(May 1998). "Identification and characterization of a novel human aldosereductase-like gene". The Journal of Biological Chemistry. 273 (19): 11429–35...
Tolrestat (INN) (AY-27773) is an aldosereductase inhibitor which was approved for the control of certain diabetic complications. While it was approved...
is an aldosereductase inhibitor being investigated for treatment of diabetic complications including neuropathy and retinopathy. Aldosereductase is an...
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