This article is missing information about what the chemical structures of
A1, A2, B1, B2 each are. The Abamectin pic can be reused, just need one more R group according to YoongKim04. Please expand the article to include this information. Further details may exist on the talk page.(September 2023)
Skeletal structure of the 8 different natural avermectins[1]
The avermectins are a series of drugs and pesticides used to treat parasitic worm infestations and to reduce insect pests. They are a group of 16-membered macrocyclic lactone derivatives with potent anthelmintic and insecticidal properties.[2][3] These naturally occurring compounds are generated as fermentation products by Streptomyces avermitilis, a soil actinomycete. Eight different avermectins were isolated in four pairs of homologue compounds (A1, A2, B1, B2), with a major (a-component) and minor (b-component) component usually in ratios of 80:20 to 90:10.[3] Avermectin B1, a mixture of B1a and B1b, is the drug and pesticide abamectin. Other anthelmintics derived from the avermectins include ivermectin, selamectin, doramectin, eprinomectin.
Half of the 2015 Nobel Prize in Physiology or Medicine was awarded to William C. Campbell and Satoshi Ōmura for discovering avermectin,[4] "the derivatives of which have radically lowered the incidence of river blindness and lymphatic filariasis, as well as showing efficacy against an expanding number of other parasitic diseases."
^Cite error: The named reference YoonKim2004 was invoked but never defined (see the help page).
^Ōmura, Satoshi; Shiomi, Kazuro (2007). "Discovery, chemistry, and chemical biology of microbial products". Pure and Applied Chemistry. 79 (4): 581–591. doi:10.1351/pac200779040581.
^ abPitterna, Thomas; Cassayre, Jérôme; Hüter, Ottmar Franz; Jung, Pierre M.J.; Maienfisch, Peter; Kessabi, Fiona Murphy; Quaranta, Laura; Tobler, Hans (2009). "New ventures in the chemistry of avermectins". Bioorganic & Medicinal Chemistry. 17 (12): 4085–4095. doi:10.1016/j.bmc.2008.12.069. PMID 19168364.
^Cite error: The named reference Nobel was invoked but never defined (see the help page).
The avermectins are a series of drugs and pesticides used to treat parasitic worm infestations and to reduce insect pests. They are a group of 16-membered...
Abamectin (also called avermectin B1) is a widely used insecticide and anthelmintic. Abamectin, is a member of the avermectin family and is a natural fermentation...
ash trees. Emamectin is derived from avermectin B1, also known as abamectin, a mixture of the natural avermectin B1a and B1b. Emamectin has also shown...
or applied to the skin for external infestations. It belongs to the avermectin family of medications. William Campbell and Satoshi Ōmura won the 2015...
of circular chromosomes. Avermectins are industrially derived from the fermentation products of S. avermitilis. Avermectin itself was discovered by the...
ticks and mange (and other ectoparasites). Doramectin is a derivative of avermectin. Similarly to other drugs of this family, it is produced by fermentation...
The milbemycins are a group of macrolides chemically related to the avermectins and were first isolated in 1972 from Streptomyces hygroscopicus. They...
Eprinomectin is an avermectin used as a veterinary topical endectocide. It is a mixture of two chemical compounds, eprinomectin B1a and B1b. "Eprinex Pour-On...
by skin scrapings. Demodectic mange in dogs can also be managed with avermectins, although there are few countries which license these drugs, which are...
Spinosyn A resembles a GABA antagonist and is comparable to the effect of avermectin on insect neurons. Spinosyn A is highly active against neonate larvae...
leaving most of the larva behind. Oral use of ivermectin, an antiparasitic avermectin medicine, has proven to be an effective and noninvasive treatment that...
year's Nobel prize in Physiology or Medicine for the discovery of the drug avermectin, which, in the further developed form ivermectin, has decreased the occurrence...
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