In pharmacology, augmented renal clearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication through the kidneys. In many cases, it is observed as a measured creatinine clearance above that which is expected given the patient's age, gender, and other factors. The phenomenon is most commonly observed in patients with neurologic damage, sepsis, major trauma, or burns.
Augmented renal clearance can be caused by increased fluid administration, certain medications, and critical illnesses. It can lead to failure of treatment in people due to a decrease in drug concentrations, increase in clearance, or shorter half life. Many medications require adjustment to account for the changed clearance in people with ARC, notably some antibiotics.
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In pharmacology, augmentedrenalclearance (ARC) is a phenomenon where certain critically ill patients may display increased clearance of a medication...
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2023-04-30. Xiao Q, Zhang H, Wu X, Qu J, Qin L, Wang C (2022). "AugmentedRenalClearance in Severe Infections-An Important Consideration in Vancomycin...
Center, a center founded by electrical engineer Douglas Engelbart Augmentedrenalclearance, a pharmacokinetic consideration in critically ill persons Australian...
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days of dosing. Renal excretion occurs by both glomerular filtration and tubular secretion as evidenced by the high rate of renalclearance (approximately...
diuretics, can increase blood uric acid levels by interfering with renalclearance. Tumor lysis syndrome, a metabolic complication of certain cancers...
December 2011, which include hypocalcaemia and severe renal impairment with a creatinine clearance of less than 35 ml/min. A rare complication that has...
excreted unchanged. Renalclearances were reported to be 146–280 ml/min, a plasma clearance of 167 ml/min/1,73m2 and a renalclearance of 125 ml/min/1,73m2...
rate, leading to oliguria with a concomitant reduction in creatinine clearance. Renal insufficiency is always progressive with an inferior prognosis, with...
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variety of malignancies, including renal cell carcinoma (temsirolimus) and pancreatic cancer, breast cancer, and renal cell carcinoma (everolimus). The...
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this change can be explained by increased synaptic release or by reduced clearance of glutamate. ... DHK-sensitive, EAAT2 uptake was not altered by AMPH...
of an organ such as a hepatic segment, a bronchopulmonary segment or a renal lobe. Excision is the resection of only part of an organ, tissue or other...
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and should be monitored for such. Decreased renal function associated with aging leads to decreased clearance of the drug, resulting in narrow therapeutic...
because of increased clearance – and factor VIII, which is related to thrombotic risk . A number of acquired conditions augment the risk of thrombosis...
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