Atipamezole , sold under the brand name Antisedan among others, is a synthetic α2 adrenergic receptor antagonist used for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Its reversal effect works by competing with the sedative for α2-adrenergic receptors and displacing them. It is mainly used in veterinary medicine, and while it is only licensed for dogs and for intramuscular use, it has been used intravenously, as well as in cats and other animals(intravenous use in cats and dogs is not recommended due to the potential for cardiovascular collapse. This occurs due to profound hypotension caused by reversal of the alpha 1 effects while the reflex bradycardia is still in effect.). There is a low rate of side effects, largely due to atipamezole's high specificity for the α2-adrenergic receptor. Atipamezole has a very quick onset, usually waking an animal up within 5 to 10 minutes.[medical citation needed]
It was originally released in 1996.[7] It is available in as a generic medication.[8]
^"Antisedan Product information". health-products.canada.ca. 24 March 2011. Retrieved 5 April 2024.
^"Antisedan- atipamezole hydrochloride injection, solution". DailyMed. 18 June 2020. Retrieved 5 April 2024.
^"Contrased- atipamezole hydrochloride injection, solution". DailyMed. 1 March 2024. Retrieved 5 April 2024.
^"Cropamezole- atipamezole hydrochloride injection, solution". DailyMed. 26 December 2023. Retrieved 5 April 2024.
^"Revertased- atipamezole hydrochloride injection, solution". DailyMed. 14 September 2023. Retrieved 5 April 2024.
^"Revertidine- atipamezole hydrochloride injection, solution". DailyMed. 12 January 2023. Retrieved 5 April 2024.
^Ettinger SJ, Feldman EC (2009). Textbook of Veterinary Internal Medicine - eBook (7th ed.). Elsevier Health Sciences. p. 61. ISBN 978-1-4377-0282-8.
^"Atipamezole". Drugs.com. Retrieved 7 August 2019.
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