Armodafinil (trade name Nuvigil) is the enantiopure compound of the eugeroic modafinil (Provigil).[3] It consists of only the (R)-(−)-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc.[4] and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.[5][6] In 2016, the FDA granted Mylan rights for the first generic version of Cephalon's Nuvigil to be marketed in the U.S.[7]
Because armodafinil has a longer half-life than modafinil does, it may be more effective at improving wakefulness in patients with excessive daytime sleepiness.[8]
^"Prescription medicines: registration of new chemical entities in Australia, 2015". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-03.
^Engber TM, Koury EJ, Dennis SA, Miller MS, Contreras PC, Bhat RV (January 1998). "Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil". Neuroscience Letters. 241 (2–3): 95–98. doi:10.1016/s0304-3940(97)00962-2. PMID 9507929. S2CID 24419972.
^"NUVIGIL (armodafinil) tablets, for oral use" (PDF). Cephalon, Inc., Teva Pharmaceutical Industries Ltd. U.S. Food and Drug Administration. Archived from the original (PDF) on 2018-01-07. Retrieved 2013-11-23.
^"CDER Drug and Biologic Approvals for Calendar Year 2007" (PDF). Archived from the original (PDF) on February 3, 2014. Retrieved January 21, 2008.
^"Search results from the "OB_Rx" table for query on "021875."", Orange Book, U.S. Food and Drug Administration, March 2012, retrieved April 30, 2012
^"Mylan Launches First Generic of Nuvigil® Tablets". MediaRoom. Archived from the original on 2017-02-11. Retrieved February 9, 2017.
^Darwish M, Kirby M, Hellriegel ET, Robertson P (2009). "Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives: analysis of data from three randomized, single-dose, pharmacokinetic studies". Clinical Drug Investigation. 29 (9): 613–623. doi:10.2165/11315280-000000000-00000. PMID 19663523. S2CID 6607186.
Armodafinil (trade name Nuvigil) is the enantiopure compound of the eugeroic modafinil (Provigil). It consists of only the (R)-(−)-enantiomer of the racemic...
bipolar disorder who are in a remission state. Whereas modafinil and armodafinil are approved for narcolepsy, they have been repurposed as adjunctive...
the enantiopure isolation of the (S) enantiomer of modafinil. Unlike armodafinil, esmodafinil has never been marketed on its own. Esmodafinil is suspected...
DRI action, which may or may not be clinically-relevant: adrafinil, armodafinil, bupropion, mazindol, modafinil, nefazodone, sertraline, and sibutramine...
and, consequently, have a lower addictive potential. Modafinil and armodafinil are each thought to act as selective, weak, atypical dopamine reuptake...
antagonist. Aplindore Aripiprazole Armodafinil – although primarily thought to be a weak DAT inhibitor, armodafinil is also a D2 partial agonist. Modafinil...
disorder which may cure the person from the EDS. Drugs like modafinil, armodafinil, Xyrem (sodium oxybate) oral solution, have been approved as treatment...
found an increase in alertness and attentional performance. Eugeroics (armodafinil and modafinil) – are classified as "wakefulness-promoting agents"; modafinil...
than certain other wakefulness-promoting agents including modafinil, armodafinil, and pitolisant. Solriamfetol is available in the form of 75 and 150 mg...
MA (March 2020). "Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: A meta-analysis of randomized controlled trials"...
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