Amcinonide information

Amcinonide
Clinical data
Trade names	Cyclocort
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical
ATC code	D07AC11 (WHO) ;
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Urine and bile
Identifiers
	IUPAC name 2-[(1S,2S,4R,8S,9S,11S,12R,13S)-12'-fluoro-11'-hydroxy-9',13'-dimethyl-16'-oxo-5',7'-dioxaspiro[cyclopentane-1,6'-pentacyclo[10.8.0.02,9.04,8.013,18]icosane]-14',17'-dien-8'-yl]-2-oxoethyl acetate;
CAS Number	51022-69-6 ;
PubChem CID	443958;
IUPHAR/BPS	7060;
DrugBank	DB00288 ;
ChemSpider	392009 ;
UNII	423W026MA9;
KEGG	D01387 ;
ChEBI	CHEBI:31199 ;
ChEMBL	ChEMBL1200732 ;
CompTox Dashboard (EPA)	DTXSID6045905 ;
ECHA InfoCard	100.051.724
Chemical and physical data
Formula	C28H35FO7
Molar mass	502.579 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.33 g/cm3
Boiling point	635.9 °C (1,176.6 °F)
	SMILES O=C(OCC(=O)[C@]45OC6(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1CC[C@@H]23)C)C)CCCC6)C;
	InChI InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1 ; Key:ILKJAFIWWBXGDU-MOGDOJJUSA-N ;
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Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis.^[1]^[2] Amcinonide can also be classified as a multi-functional small molecule corticosteroid, which has been approved by the FDA and is currently marketed as an ointment, lotion, or cream.^[3] It acts as both a transcription factor for responses to glucocorticoids and modulator for other transcription factors while also regulating phospholipase A2 activity.^[4]

^ Drugs.com: Amcinonide topical
^ Bickers DR (August 1984). "A comparative study of amcinonide and halcinonide in the treatment of eczematous dermatitis". Cutis. 34 (2): 190–4. PMID 6383735.
^ DrugBank.ca: Amcinonide Pharmacoeconomics
^ PubChem.gov:Amcinonide

[1] Drugs.com: Amcinonide topical

[2] Bickers DR (August 1984). "A comparative study of amcinonide and halcinonide in the treatment of eczematous dermatitis". Cutis. 34 (2): 190–4. PMID 6383735.

[3] DrugBank.ca: Amcinonide Pharmacoeconomics

[4] PubChem.gov:Amcinonide

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