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Alpha beta barrel information


An alpha/beta barrel is a protein fold formed by units composed of a short α-helix followed by two anti-parallel β-strands, followed by an α-helix and a β-strand; the three β-strands form a β-sheet that runs parallel to the barrel and the α-helix is in the outside of the barrel but does not contact the α-helices of the other repeats like in TIM barrels.


The protein structures known for this fold come proteins from the eukaryotic and archaeal initiation factor 6 family, namely the Methanococcus jannaschii aIF6 and Saccharomyces cerevisiae eIF6,[1] and from the eIF6 from Dictyostelium discoideum.[2]

These alpha/beta barrels are commonly occurring motifs constructed from repetitions of the beta-alpha-beta loop motif. This alpha/beta barrel is a domain of pyruvate kinase enzyme. [3]

  1. ^ Groft CM, Beckmann R, Sali A, Burley SK (December 2000). "Crystal structures of ribosome anti-association factor IF6". Nat. Struct. Biol. 7 (12): 1156–64. doi:10.1038/82017. PMID 11101899. S2CID 35762049.
  2. ^ Weis F, Giudice E, Churcher M, Jin L, Hilcenko C, Wong CC, Traynor D, Kay RR, Warren AJ (November 2015). "Mechanism of eIF6 release from the nascent 60S ribosomal subunit". Nat. Struct. Mol. Biol. 22 (11): 914–9. doi:10.1038/nsmb.3112. PMC 4871238. PMID 26479198.
  3. ^ Lee, J. C.; Herman, P. (2011). Structural and functional energetic linkages in allosteric regulation of muscle pyruvate kinase. Methods in Enzymology. Vol. 488. pp. 185–217. doi:10.1016/B978-0-12-381268-1.00008-2. ISBN 9780123812681. PMID 21195229.

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Alpha beta barrel

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An alpha/beta barrel is a protein fold formed by units composed of a short α-helix followed by two anti-parallel β-strands, followed by an α-helix and...

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TIM barrel

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The TIM barrel (triose-phosphate isomerase), also known as an alpha/beta barrel,: 252  is a conserved protein fold consisting of eight alpha helices (α-helices)...

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Staphylococcus aureus alpha toxin

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member of the pore forming beta-barrel toxin family. This toxin consists mostly of beta-sheets (68%) with only about 10% alpha-helices. The hly gene on...

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Transmembrane protein

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it. There are two basic types of transmembrane proteins: alpha-helical and beta barrels. Alpha-helical proteins are present in the inner membranes of bacterial...

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Alanine racemase

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two domains, an eight-stranded alpha/beta barrel at the N terminus, and a C-terminal domain essentially composed of beta-strand. A model of the two domain...

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Peripheral membrane protein

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form transmembrane alpha-helical or beta-barrel channels. Such transformations occur in pore forming toxins such as colicin A, alpha-hemolysin, and others...

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Dihydroorotate dehydrogenase

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inhibit DHODH. Human DHODH has two domains: an alpha/beta-barrel domain containing the active site and an alpha-helical domain that forms the opening of a...

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Ornithine decarboxylase

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homodimer. Each monomer contains a barrel domain, consisting of an alpha-beta barrel, and a sheet domain, composed of two beta-sheets. The domains are connected...

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Wallemia mellicola

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considered significant, including heat shock protein, stress responsive alpha-beta barrel, and amino acid transporter, and they may be responsible for the survival...

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ABM domain

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which is involved in actinorhodin biosynthesis, reveals a dimeric alpha+beta barrel topology. There is also a conserved histidine that is likely to be...

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Neopullulanase

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carboxyl-terminus within a TIM barrel (also known as an alpha/beta barrel), an alpha/beta protein fold structure consisting of eight parallel beta-strands connected...

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Protein domain

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Lesk AM, Brändén CI, Chothia C (1989). "Structural principles of alpha/beta barrel proteins: the packing of the interior of the sheet". Proteins. 5 (2):...

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Beta sheet

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The beta sheet (β-sheet, also β-pleated sheet) is a common motif of the regular protein secondary structure. Beta sheets consist of beta strands (β-strands)...

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Glucansucrase

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Jespersen HM, Svensson B (January 1996). "A circularly permuted alpha-amylase-type alpha/beta-barrel structure in glucan-synthesizing glucosyltransferases". FEBS...

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Euler angles

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{d}}V\propto \sin \beta \cdot {\textrm {d}}\alpha \cdot {\textrm {d}}\beta \cdot {\textrm {d}}\gamma } , where ( β , α ) {\displaystyle (\beta ,\alpha )} parametrise...

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Beer measurement

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contain lupulones, or beta acids; these beta acids are not considered in the initial bittering of the wort as much as their alpha acid counterparts since...

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TPI1

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8 exterior alpha helices surrounding 8 interior beta strands, which form a conserved structural domain called a closed alpha/beta barrel (αβ) or more...

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Xylose isomerase

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based on eight alpha/beta barrels that create an active site holding two divalent magnesium ions. Xylose isomerase enzymes exhibit a TIM barrel fold with the...

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Transmembrane domain

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membrane-spanning protein domain. TMDs may consist of one or several alpha-helices or a transmembrane beta barrel. Because the interior of the lipid bilayer is hydrophobic...

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Glycoside hydrolase family 97

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complete (beta/alpha)8-barrel or catalytic TIM-barrel type domain. The N- and C-terminal parts of the sequences, mainly consisting of beta-strands, most...

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Hemolysin

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the moment, apiegnin and beta-cyclodextrin are thought to alleviate S.aureus pneumonia, whereas the antibodies of anti alpha-hemlysin are thought to give...

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Beta trefoil fold

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protein fold that consists of six beta hairpins, each formed by two beta strands. Together these form a beta barrel with a triangular "cap", each consisting...

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