An alpha/beta barrel is a protein fold formed by units composed of a short α-helix followed by two anti-parallel β-strands, followed by an α-helix and a β-strand; the three β-strands form a β-sheet that runs parallel to the barrel and the α-helix is in the outside of the barrel but does not contact the α-helices of the other repeats like in TIM barrels.
The protein structures known for this fold come proteins from the eukaryotic and archaeal initiation factor 6 family, namely the Methanococcus jannaschii aIF6 and Saccharomyces cerevisiae eIF6,[1] and from the eIF6 from Dictyostelium discoideum.[2]
These alpha/beta barrels are commonly occurring motifs constructed from repetitions of the beta-alpha-beta loop motif. This alpha/beta barrel is a domain of pyruvate kinase enzyme. [3]
^Groft CM, Beckmann R, Sali A, Burley SK (December 2000). "Crystal structures of ribosome anti-association factor IF6". Nat. Struct. Biol. 7 (12): 1156–64. doi:10.1038/82017. PMID 11101899. S2CID 35762049.
^Weis F, Giudice E, Churcher M, Jin L, Hilcenko C, Wong CC, Traynor D, Kay RR, Warren AJ (November 2015). "Mechanism of eIF6 release from the nascent 60S ribosomal subunit". Nat. Struct. Mol. Biol. 22 (11): 914–9. doi:10.1038/nsmb.3112. PMC 4871238. PMID 26479198.
^Lee, J. C.; Herman, P. (2011). Structural and functional energetic linkages in allosteric regulation of muscle pyruvate kinase. Methods in Enzymology. Vol. 488. pp. 185–217. doi:10.1016/B978-0-12-381268-1.00008-2. ISBN 9780123812681. PMID 21195229.
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The TIM barrel (triose-phosphate isomerase), also known as an alpha/betabarrel,: 252 is a conserved protein fold consisting of eight alpha helices (α-helices)...
member of the pore forming beta-barrel toxin family. This toxin consists mostly of beta-sheets (68%) with only about 10% alpha-helices. The hly gene on...
it. There are two basic types of transmembrane proteins: alpha-helical and betabarrels. Alpha-helical proteins are present in the inner membranes of bacterial...
two domains, an eight-stranded alpha/betabarrel at the N terminus, and a C-terminal domain essentially composed of beta-strand. A model of the two domain...
form transmembrane alpha-helical or beta-barrel channels. Such transformations occur in pore forming toxins such as colicin A, alpha-hemolysin, and others...
inhibit DHODH. Human DHODH has two domains: an alpha/beta-barrel domain containing the active site and an alpha-helical domain that forms the opening of a...
homodimer. Each monomer contains a barrel domain, consisting of an alpha-betabarrel, and a sheet domain, composed of two beta-sheets. The domains are connected...
considered significant, including heat shock protein, stress responsive alpha-betabarrel, and amino acid transporter, and they may be responsible for the survival...
which is involved in actinorhodin biosynthesis, reveals a dimeric alpha+betabarrel topology. There is also a conserved histidine that is likely to be...
Lesk AM, Brändén CI, Chothia C (1989). "Structural principles of alpha/betabarrel proteins: the packing of the interior of the sheet". Proteins. 5 (2):...
The beta sheet (β-sheet, also β-pleated sheet) is a common motif of the regular protein secondary structure. Beta sheets consist of beta strands (β-strands)...
carboxyl-terminus within a TIM barrel (also known as an alpha/betabarrel), an alpha/beta protein fold structure consisting of eight parallel beta-strands connected...
contain lupulones, or beta acids; these beta acids are not considered in the initial bittering of the wort as much as their alpha acid counterparts since...
8 exterior alpha helices surrounding 8 interior beta strands, which form a conserved structural domain called a closed alpha/betabarrel (αβ) or more...
based on eight alpha/betabarrels that create an active site holding two divalent magnesium ions. Xylose isomerase enzymes exhibit a TIM barrel fold with the...
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membrane-spanning protein domain. TMDs may consist of one or several alpha-helices or a transmembrane betabarrel. Because the interior of the lipid bilayer is hydrophobic...
the moment, apiegnin and beta-cyclodextrin are thought to alleviate S.aureus pneumonia, whereas the antibodies of anti alpha-hemlysin are thought to give...
fold into alpha-helical and, alternatively, into beta-barrel form. These two interconvertible structures have two different functions, in alpha-helix form...
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