D-Xylose isomerase tetramer from Streptomyces rubiginosus PDB 2glk.[1] One monomer is coloured by secondary structure to highlight the TIM barrel architecture.
Identifiers
EC no.
5.3.1.5
CAS no.
9023-82-9
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In enzymology, a xylose isomerase (EC 5.3.1.5) is an enzyme that catalyzes the interconversion of
D-xylose and D-xylulose. This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The isomerase has now been observed in nearly a hundred species of bacteria. Xylose-isomerases are also commonly called fructose-isomerases due to their ability to interconvert glucose and fructose. The systematic name of this enzyme class is D-xylose aldose-ketose-isomerase. Other names in common use include D-xylose isomerase, D-xylose ketoisomerase, and D-xylose ketol-isomerase.[2]
^Katz AK, Li X, Carrell HL, Hanson BL, Langan P, Coates L, Schoenborn BP, Glusker JP, Bunick GJ (2006). "Locating active-site hydrogen atoms in D-xylose isomerase: Time-of-flight neutron diffraction". Proceedings of the National Academy of Sciences. 103 (22): 8342–8347. Bibcode:2006PNAS..103.8342K. doi:10.1073/pnas.0602598103. PMC 1482496. PMID 16707576.
^Mu W, Hassanin HA, Zhou L, Jiang B (2018). "Chemistry Behind Rare Sugars and Bioprocessing". Journal of Agricultural and Food Chemistry. 66 (51): 13343–13345. doi:10.1021/acs.jafc.8b06293. PMID 30543101. S2CID 56145019.
In enzymology, a xyloseisomerase (EC 5.3.1.5) is an enzyme that catalyzes the interconversion of D-xylose and D-xylulose. This enzyme belongs to the...
most common use of isomerases in industrial applications is in sugar manufacturing. Glucose isomerase (also known as xyloseisomerase) catalyzes the conversion...
the catabolism of D-xylose: An oxido-reductase pathway is present in eukaryotic microorganisms. Prokaryotes typically use an isomerase pathway, and two oxidative...
processed into high-fructose corn syrup (HFCS) by using the enzyme D-xyloseisomerase to convert a large proportion of its glucose into sweeter fructose...
metabolic disturbances" Xyloseisomerase acts to convert fructose sugars into glucose. Dietary supplements of xyloseisomerase may improve some symptoms...
Deshpande, V. V. (1996-06-01). "Molecular and industrial aspects of glucose isomerase". Microbiological Reviews. 60 (2): 280–300. doi:10.1128/mr.60.2.280-300...
Boles E, Wiedemann B (2009). "Functional expression of a bacterial xyloseisomerase in Saccharomyces cerevisiae". Applied and Environmental Microbiology...
passing the glucose through a column that is loaded with the enzyme D-xyloseisomerase, an enzyme that is isolated from the growth medium of any of several...
building block of glycogen. Glucose can also be converted from bacterial xyloseisomerase to fructose. In addition, glucose metabolites produce all nonessential...
from soil. Streptomyces olivochromogenes produces ferulic acid. The xyloseisomerase from Streptomyces olivochromogenes is used in the food industry. Simkhada...
Hahn-Hägerdal, Bärbel (February 2003). "The Streptomyces rubiginosus xyloseisomerase is misfolded when expressed in Saccharomyces cerevisiae". Enzyme and...
Boles E, Wiedemann B (2009). "Functional expression of a bacterial xyloseisomerase in Saccharomyces cerevisiae". Appl. Environ. Microbiol. 75 (8): 2304–2311...
accomplished via overexpressing heterologous xylulose kinase and endogenous xyloseisomerase. A European patent has also demonstrated the capability of oils sourced...
enzymes encoding genes for carboxylase, cellulase and xylanase enzymes, xyloseisomerase, and carboxylesterase. Other genes coding for biosynthesis of peptides...
PMID 21076656. Parachin NS, Gorwa-Grauslund MF (May 2011). "Isolation of xyloseisomerases by sequence- and function-based screening from a soil metagenomic...
polycyclic aromatic hydrocarbons as well as the structure of the enzyme xyloseisomerase. In 1972 Glusker and structural biologist Helen M. Berman reported...
Anoxybacillus gonensis is a moderately thermophilic, xylose-utilizing, endospore-forming bacterium. It is Gram-positive and rod-shaped, with type strain...
Brat, E. Boles, B. Wiedemann: Functional expression of a bacterial xyloseisomerase in Saccharomyces cerevisiae. Applied and Environmental Microbiology...
2002). "Glucose-to-fructose conversion at high temperatures with xylose (glucose) isomerases from Streptomyces murinus and two hyperthermophilic Thermotoga...
X; Teng, M; Niu, L; Xu, C; Wang, Y (February 2000). "Structure of xyloseisomerase from Streptomyces diastaticus no. 7 strain M1033 at 1.85 A resolution"...
K (naphthoquinone) Vitamin M (folic acid) Water Wortmannin Xanthophyll Xylose Yellow fluorescent protein Zearalenone Chemical compound Organic compound...
February 2008). "Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for...
4-phosphate was found to be an inhibitor of phosphoglucose isomerase. Phosphoglucose isomerase is the second enzyme in the glycolysis pathway, and its role...
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