Acquired neuroprotection is a synaptic-activity-dependent form of adaptation in the nervous system that renders neurons more resistant to harmful conditions. The term was coined by Hilmar Bading.[1] This use-dependent enhancement of cellular survival activity requires changes in gene expression triggered by neuronal activity and nuclear calcium signaling. In rodents, components of the neuroprotective gene program can reduce brain damage caused by seizure-like activity or by a stroke.[1][2][3] In acute and chronic neurodegenerative diseases, gene regulatory events important for acquired neuroprotection are antagonized by extrasynaptic NMDA receptor signaling leading to increased vulnerability, loss of structural integrity, and bioenergetics dysfunction.[4][5]
^ abZhang, Sheng-Jia; Zou, Ming; Lu, Li; Lau, David; Ditzel, Désirée A. W.; Delucinge-Vivier, Celine; Aso, Yoshinori; Descombes, Patrick; Bading, Hilmar (2009-08-01). "Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity". PLOS Genetics. 5 (8): e1000604. doi:10.1371/journal.pgen.1000604. ISSN 1553-7404. PMC 2718706. PMID 19680447.
^Zhang, Sheng-Jia; Buchthal, Bettina; Lau, David; Hayer, Stefanie; Dick, Oliver; Schwaninger, Markus; Veltkamp, Roland; Zou, Ming; Weiss, Ursula (2011-03-30). "A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage". The Journal of Neuroscience. 31 (13): 4978–4990. doi:10.1523/JNEUROSCI.2672-10.2011. ISSN 1529-2401. PMC 6622995. PMID 21451036.
^Lau, David; Bengtson, C. Peter; Buchthal, Bettina; Bading, Hilmar (2015-08-25). "BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A". Cell Reports. 12 (8): 1353–1366. doi:10.1016/j.celrep.2015.07.038. ISSN 2211-1247. PMID 26279570.
^Hardingham, G. E.; Fukunaga, Y.; Bading, H. (2002-05-01). "Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways". Nature Neuroscience. 5 (5): 405–414. doi:10.1038/nn835. ISSN 1097-6256. PMID 11953750. S2CID 659716.
Acquiredneuroprotection is a synaptic-activity-dependent form of adaptation in the nervous system that renders neurons more resistant to harmful conditions...
system, nuclear calcium is required for long-term memory formation, acquiredneuroprotection, and the development of chronic inflammatory pain. In the heart...
cell surface. In contrast to synaptic NMDA receptors that promote acquiredneuroprotection and synaptic plasticity, extrasynaptic NMDA receptors are coupled...
adaptations in the nervous system that include memory formation and acquiredneuroprotection. The discovery of toxic signaling by extrasynaptic NMDA receptors...
formation of stable synaptic contacts. While CSPGs are very important in neuroprotection, this indicates that CSPGs may not be the only molecules important...
Bresolin N, Comi GP, Corti S (June 2011). "Beta-lactam antibiotic offers neuroprotection in a spinal muscular atrophy model by multiple mechanisms" (PDF). Experimental...
CI (10 October 2011). "Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid". Life Sciences. 89 (15–16):...
endogenous neuroprotection and neurorestoration pathways by the release of cytokines and trophic factors. Although activation of endogenous neuroprotection and...
S2CID 254384149. Elkahloun AG, Saavedra JM (March 2020). "Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence:...
find treatments that interfere with the damage processes. Although neuroprotection methods to decrease secondary injury have been the subject of interest...
Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma". Molecules. 27 (13): 4297...
books, entitled Optics for Ophthalmologists: A Board-Review Manual, Neuroprotection: Implication for Eye Disease, New Methods of Sensory Visual Testing...
progressive patients (PPMS) do have some kind of problem to protect neuroprotection against demyelination or oligodendrocytes, compared to healthy subjects...
Stanton PK, Potter PE, Aguilar J, Decandia M, Moskal JR (August 2009). "Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13"...
of a research project. The arenas of research can be as diverse as neuroprotection, myocardial protection, blood conservation strategies, and port access...
impermeable membranes to modulate the stars of the neurovascular unit for neuroprotection". Proceedings of the National Academy of Sciences. 115 (52): E12333–E12342...
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