185 to 190 °C (365 to 374 °F; 458 to 463 K) (decomposes)
Hazards
Safety data sheet (SDS)
External MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Nverify (what is YN ?)
Infobox references
Chemical compound
Quinolinic acid (abbreviated QUIN or QA), also known as pyridine-2,3-dicarboxylic acid, is a dicarboxylic acid with a pyridine backbone. It is a colorless solid. It is the biosynthetic precursor to niacin.[1]
Quinolinic acid is a downstream product of the kynurenine pathway, which metabolizes the amino acid tryptophan. It acts as an NMDA receptor agonist.[2]
Quinolinic acid has a potent neurotoxic effect. Studies have demonstrated that quinolinic acid may be involved in many psychiatric disorders, neurodegenerative processes in the brain, as well as other disorders. Within the brain, quinolinic acid is only produced by activated microglia and macrophages.[3]
^Cite error: The named reference Ashihara was invoked but never defined (see the help page).
^Misztal M, Frankiewicz T, Parsons CG, Danysz W (January 1996). "Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantine". Eur. J. Pharmacol. 296 (1): 1–8. doi:10.1016/0014-2999(95)00682-6. PMID 8720470.
^Guillemin, G.; Smith, Danielle G.; Smythe, George A.; Armati, Patricia J.; Brew, George J. (2003). "Expression of the Kynurenine Pathway Enzymes in Human Microglia and Macrophages". Developments in Tryptophan and Serotonin Metabolism. Advances in Experimental Medicine and Biology. Vol. 527. pp. 105–12. doi:10.1007/978-1-4615-0135-0_12. ISBN 978-0-306-47755-3. PMID 15206722.
Quinolinicacid (abbreviated QUIN or QA), also known as pyridine-2,3-dicarboxylic acid, is a dicarboxylic acid with a pyridine backbone. It is a colorless...
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kynurenine pathway include tryptophan, kynurenine, kynurenic acid, xanthurenic acid, quinolinicacid, and 3-hydroxykynurenine. The kynurenine pathway is responsible...
of the uncharacterized site. Aspartate Ibotenic acid Tetrazolylglycine Stone TW (1989). Quinolinicacid and the kynurenines. CRC Press. ISBN 978-0-8493-6592-8...
/ˈɡlaɪsiːn/ ) is an amino acid that has a single hydrogen atom as its side chain. It is the simplest stable amino acid (carbamic acid is unstable). In the...
acid is a group of organic compounds which are dicarboxylic derivatives of pyridine. Pyridinedicarboxylic acid comes in several isomers: Quinolinic acid...
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all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It...
County Clare, a village in County Clare, Ireland QUIN, quinolinicacid, a dicarboxylic acid with a pyridine backbone Quin House, nickname for Algonquin...
microalgae, together with spermine and spermidine. Putrescine reacts with adipic acid to yield the polyamide nylon 46, which is marketed by DSM under the trade...
magnesium-based engine. Magnesium also reacts exothermically with most acids such as hydrochloric acid (HCl), producing magnesium chloride and hydrogen gas, similar...
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