This article is missing information about history of discovery — who gave it this codename?. Please expand the article to include this information. Further details may exist on the talk page.(December 2022)
AM404, also known as N-arachidonoylphenolamine,[1][2] is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action[3] and anticonvulsant effects.[4] Chemically, it is the amide formed from 4-aminophenol and arachidonic acid.
^Nakamura S, Nonaka T, Komatsu S, Yamada T, Yamamoto T (February 2022). "Oral acetaminophen-induced spinal 5-hydroxytriyptamine release produces analgesic effects in the rat formalin test". Biomedicine & Pharmacotherapy. 146: 112578. doi:10.1016/j.biopha.2021.112578. PMID 34959121. S2CID 245483361.
^Ottani A, Leone S, Sandrini M, Ferrari A, Bertolini A (February 2006). "The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors". European Journal of Pharmacology. 531 (1–3): 280–281. doi:10.1016/j.ejphar.2005.12.015. PMID 16438952.
AM404, also known as N-arachidonoylphenolamine, is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action...
to the COX-2 isozyme are called COX-2 inhibitors. The active metabolite (AM404) of paracetamol is a COX inhibitor, a fact to which some or all of its therapeutic...
cyclooxygenase and actions of its metabolite N-arachidonoylphenolamine (AM404). Supporting the first mechanism, pharmacologically and in its side effects...
disinhibiting pain perception. However, this re-uptake can be blocked by AM404, elongating the duration of pain inhibition. Howard Hughes is thought to...
Canada) is metabolically combined with arachidonic acid by FAAH to form AM404. This metabolite of paracetamol is a potent agonist at the TRPV1 vanilloid...
Multiple; inhibits prostaglandin synthesis in the CNS, an active metabolite, AM404, is an anandamide reuptake inhibitor. PO, IV, IM, rectal. Protein binding...
endocannabinoid anandamide has also been shown to act on TRPV1 receptors. AM404—an active metabolite of paracetamol (also known as acetaminophen)—that serves...
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