ADAM 17 endopeptidase (EC 3.4.24.86, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme.[1] This enzyme catalyses the following chemical reaction
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
This enzyme belongs to the peptidase family M12.
^Black RA (January 2002). "Tumor necrosis factor-alpha converting enzyme". The International Journal of Biochemistry & Cell Biology. 34 (1): 1–5. doi:10.1016/S1357-2725(01)00097-8. PMID 11733179.
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ADAM17endopeptidase (EC 3.4.24.86, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme. This enzyme catalyses the following chemical reaction...
to: Transcatheter arterial chemoembolization, a medical procedure ADAM17endopeptidase, an enzyme Chlorotrianisene, a synthetic estrogen Tamil All Character...
metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of...
metalloexopeptidases (EC number: 3.4.17). Endopeptidases, metalloendopeptidases (3.4.24). Well known metalloendopeptidases include ADAM proteins and matrix metalloproteinases...
position. Renin activates the renin–angiotensin system by using its endopeptidase activity to cleave the peptide bonds between leucine and valine residues...
are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins. The...
metalloproteinases (MMPs) are a large multigene family of zinc-dependent endopeptidases. The collective MMP family is capable of degrading all known ECM macromolecules...
the secondary structures are also conserved. Pepsin (pH 1.3), Asp-N endopeptidase, N-terminal Glutamate and Proteinase K all had 50 or more cleavage sites...
are coded by the same mRNA". Nucleic Acids Research. 11 (17): 5811–5819. doi:10.1093/nar/11.17.5811. PMC 326319. PMID 6310515. Yang F, Brune JL, Baldwin...
chromosome in the locus 3q21-q23. In oxen, the coding sequence consists of 17 exons and has a length of about 34,500 nucleotide pairs. Exons of the lactoferrin...
doi:10.1126/science.283.5401.543. PMID 9915703. Schütze S, Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse ML, Heinrich M, Wickel M, Krönke M (April...
serum corticosterone is bound to transcortin. Aldosterone - Approximately 17% of serum aldosterone is bound to transcortin, while another 47% is bound...
toxins found in the venom of western diamondback rattlesnake. This endopeptidase has a length of 419 amino acid residues. The metalloproteinase disintegrin-like...
1073/pnas.1436338100. PMC 166231. PMID 12829790. Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M, Vadlamudi RK, Kumar R (January 2001). "Transcriptional...
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