The zona reticularis (sometimes, reticulate zone) is the innermost layer of the adrenal cortex, lying deep to the zona fasciculata and superficial to the adrenal medulla. The cells are arranged cords that project in different directions giving a net-like appearance (L. reticulum - net).[1]
Cells in the zona reticularis produce precursor androgens including dehydroepiandrosterone (DHEA) and androstenedione from cholesterol.[2] DHEA is further converted to DHEA-sulfate via a sulfotransferase, SULT2A1.[3] These precursors are not further converted in the adrenal cortex if the cells lack 17β-Hydroxysteroid dehydrogenase. Instead, they are released into the blood stream and taken up in the testicles and ovaries to produce testosterone and the estrogens respectively.
ACTH partially regulates adrenal androgen secretion,[4] also CRH.[5][6]
In humans, the reticularis layer does contain 17α-hydroxylase; this hydroxylates pregnenolone, which is then converted to cortisol by a mixed function oxidase. In rodents, the lack of 17α-hydroxylase results in the synthesis of corticosterone instead of cortisol as in the human.[citation needed]
Adrenal gland (zona reticularis layer).
^Histology: A Text and Atlas, 5th ed. Ross and Pawlina.[page needed]
^Rainey WE, Nakamura Y (February 2008). "Regulation of the Adrenal Androgen Biosynthesis". J. Steroid Biochem. Mol. Biol. 108 (3–5): 281–6. doi:10.1016/j.jsbmb.2007.09.015. PMC 2699571. PMID 17945481.
^Pediatric Adrenal Insufficiency (Addison Disease) at eMedicine
^Ibáñez L, Potau N, Marcos MV, de Zegher F (September 1999). "Corticotropin-releasing hormone as adrenal androgen secretagogue". Pediatric Research. 46 (3): 351–3. doi:10.1203/00006450-199909000-00018. PMID 10473054.
^Coppola, Christopher P.; Merrell, Ronald C. (2001). "Neoplasms of the Adrenal and Endocrine Pancreas in the Elderly". In Rosenthal, Ronnie A.; Zenilman, Michael E.; Katlic, Mark R. (eds.). Principles and Practice of Geriatric Surgery. Springer. pp. 301–21. doi:10.1007/978-1-4757-3432-4_22. ISBN 978-1-4757-3432-4.
The zonareticularis (sometimes, reticulate zone) is the innermost layer of the adrenal cortex, lying deep to the zona fasciculata and superficial to the...
gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zonareticularis. Each zone is responsible for producing specific...
itself is divided into three main zones: the zona glomerulosa, the zona fasciculata and the zonareticularis. The adrenal cortex produces three main types...
dehydroepiandrosterone). The main source of androgens will come from the zona reticularis region. In certain animals such as rodents, the lack of 17alpha-hydroxylase...
production and release of cortisol and androgens by the zona fasiculata and zonareticularis, respectively. ACTH is also related to the circadian rhythm...
pyknotic nuclei (arrows) (400x). Pyknotic nuclei are often found in the zonareticularis of the adrenal gland. They are also found in the keratinocytes of the...
Dehydroepiandrosterone androgen DHEA testes, ovary, kidney Zona fasciculata and Zonareticularis cells of kidney theca cells of ovary Leydig cells of testes...
which relays the signal to the adrenal cortex. Here, the zona fasciculata and zonareticularis, in response to ACTH, secrete glucocorticoids, in particular...
adrenal androgens, is composed of 19-carbon steroids synthesized in the zonareticularis, the innermost layer of the adrenal cortex. Adrenal androgens function...
system (RAAS), not ACTH. Adrenal insufficiency can also affect the zonareticularis and disrupt production of androgens, which are precursors to testosterone...
dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) from the zonareticularis of the adrenal glands with age. Levels of adrenal androgens start to...
expressed in many tissues and cell types, including the zonareticularis and zona fasciculata (but not zona glomerulosa) of the adrenal cortex as well as gonadal...
been found to competitively inhibit TRPV1. DHEA is produced in the zonareticularis of the adrenal cortex under the control of adrenocorticotropic hormone...
the brainstem, such as the locus coeruleus. It also occurs in the zonareticularis of the adrenal gland. The melanin in the skin is produced by melanocytes...
in humans also produces aldosterone in the zona glomerulosa and some sex hormones in the zonareticularis, cortisol is its main secretion in humans and...
(on car license plates) Zirconium (symbol: Zr), a chemical element Zonareticularis, an anatomical feature of the adrenal cortex .zr, an abolished Internet...
comprises three concentric zones including the zona glomerulosa, zona fasciculata, and zonareticularis that under normal conditions respond to body's...
membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte. Theca of follicle, antrum and liquor folliculi...
cells of the zona fasciculata of the adrenal cortex. ACTH can also regulate secretion of gonadocorticoids from the cells of the zonareticularis since they...
synthesized in the innermost layer of the adrenal cortex known as the zonareticularis. These hormones, such as estrogen in females and testosterone in males...
hormone, adrenocorticotropic hormone (ACTH), that signals the zona fasciculata and zonareticularis to produce their steroids. When the pituitary is unable...
and to inhibit the P2X receptor. DHEA and DHEA-S are produced in the zonareticularis of the adrenal cortex under the control of adrenocorticotropic hormone...
made of three zones: zona glomerulosa, zona fasciculata and zonareticularis. The main zone that expresses MC2 and MRAP is the zona fasciculata. Both proteins...
Cells of the Zona fasciculata produce glucocorticoids Cells of the zonareticularis produce androgens Theca Interna cell ovarian follicle secreting estrogen...
neonatal period, there is increased sebum production through an enlarged zonareticularis (an androgen producing area) on the fetal adrenal gland that gradually...
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