The zona fasciculata (sometimes, fascicular or fasciculate zone) constitutes the middle and also the widest zone of the adrenal cortex, sitting directly beneath the zona glomerulosa. Constituent cells are organized into bundles or "fascicles".
The zona fasciculata chiefly produces glucocorticoids (mainly cortisol in humans), which regulate the metabolism of glucose. Glucocorticoid production is stimulated by adrenocorticotropic hormone (ACTH), which is released from the anterior pituitary, especially in times of stress as part of the fight-or-flight response. The zona fasciculata also generates a small amount of weak androgens (e.g., dehydroepiandrosterone). The main source of androgens will come from the zona reticularis region. In certain animals such as rodents, the lack of 17alpha-hydroxylase results in the synthesis of corticosterone instead of cortisol.
Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing's syndrome. The genetic disorder McCune-Albright syndrome can also present as Cushing's syndrome in affected patients.
The zonafasciculata (sometimes, fascicular or fasciculate zone) constitutes the middle and also the widest zone of the adrenal cortex, sitting directly...
adrenal gland. It is divided into three separate zones: zona glomerulosa, zonafasciculata and zona reticularis. Each zone is responsible for producing specific...
cortex itself is divided into three main zones: the zona glomerulosa, the zonafasciculata and the zona reticularis. The adrenal cortex produces three main...
the zona glomerulosa reflects the regenerative feature of these cells, which would lose NCAM immunoreactivity after moving to the zonafasciculata. However...
The zona reticularis (sometimes, reticulate zone) is the innermost layer of the adrenal cortex, lying deep to the zonafasciculata and superficial to the...
are chiefly produced in the zonafasciculata of the adrenal cortex, whereas mineralocorticoids are synthesized in the zona glomerulosa. Cortisol (or hydrocortisone)...
In the human endocrine system, a spongiocyte is a cell in the zonafasciculata of the adrenal cortex containing lipid droplets that show pronounced vacuolization...
known as hydrocortisone. It is produced in many animals, mainly by the zonafasciculata of the adrenal cortex in the adrenal gland. It is produced in other...
pituitary) ACTH – Stimulates the synthesis and release of cortisol (zonafasciculata of the adrenal cortex in the adrenal glands) TSH – Stimulates the synthesis...
finger, a protein domain that interacts with zinc ion to bind to DNA Zonafasciculata, the middle zone of the adrenal cortex Zelda Fitzgerald, wife of F...
hair. Dehydroepiandrosterone androgen DHEA testes, ovary, kidney Zonafasciculata and Zona reticularis cells of kidney theca cells of ovary Leydig cells...
glucocorticoids (primarily, cortisol) in the zonafasciculata and mineralocorticoids (primarily, aldosterone) in the zona glomerulosa to regulate metabolism, blood...
within the zona glomerulosa at the outer edge of the adrenal cortex; 11β-hydroxylase is found in the zona glomerulosa and zonafasciculata. Aldosterone...
expressed in many tissues and cell types, including the zona reticularis and zonafasciculata (but not zona glomerulosa) of the adrenal cortex as well as gonadal...
glucocorticoid steroid hormones from adrenal cortex cells, especially in the zonafasciculata of the adrenal glands. ACTH acts by binding to cell surface ACTH receptors...
cortex comprises three concentric zones including the zona glomerulosa, zonafasciculata, and zona reticularis that under normal conditions respond to body's...
L-type, and T-type voltage-dependent calcium channels are present in the zona glomerulosa of the human adrenal gland, and CCBs can directly influence the...
ACTH, which relays the signal to the adrenal cortex. Here, the zonafasciculata and zona reticularis, in response to ACTH, secrete glucocorticoids, in...
synthesized in the middle layer of the adrenal cortex known as the zonafasciculata. These hormones regulate the processing of proteins, fats, and carbohydrates...
membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte. Theca of follicle, antrum and liquor folliculi...
to occur in young women with the adenoma in the cortisol secreting zonafasciculata. Adenomas without this mutation tend to occur in older men with resistant...
the cells of the zonafasciculata of the adrenal cortex. ACTH can also regulate secretion of gonadocorticoids from the cells of the zona reticularis since...
found within the zona glomerulosa at the outer edge of the adrenal cortex; 11β-hydroxylase is found in the zonafasciculata and zona glomerulosa. In general...
cortisol is the primary glucocorticoid that is produced primarily in the zonafasciculata of the adrenal cortex. Corticosterone has only weak glucocorticoid...
hormone, adrenocorticotropic hormone (ACTH), that signals the zonafasciculata and zona reticularis to produce their steroids. When the pituitary is unable...
(AVP). Steroid hormones known as "glucocorticoids" are produced in the zonafasciculata of the adrenal cortex and numerous other extra-adrenal organs, such...
Global Information
