stimulated by retinoic acid gene 6 homolog (mouse)
Identifiers
Symbol
STRA6
NCBI gene
64220
HGNC
30650
OMIM
610745
PDB
5sy1
RefSeq
NM_022369
UniProt
Q7Z3U9
Other data
Locus
Chr. 15 q24.1
Search for
Structures
Swiss-model
Domains
InterPro
Vitamin A receptor, Stimulated by retinoic acid 6 or STRA6 protein was originally discovered as a transmembrane cell-surface receptor for retinol-binding protein.[1][2][3] STRA6 is unique as it functions both as a membrane transporter and a cell surface receptor, particularly as a cytokine receptor. In fact, STRA6 may be the first of a whole new class of proteins that might be known as "cytokine signaling transporters."[4] STRA6 is primarily known as the receptor for retinol binding protein and for its relevance in the transport of retinol to specific sites such as the eye (Vitamin A).[5] It does this through the removal of retinol (ROH) from the holo-Retinol Binding Protein (RBP) and transports it into the cell to be metabolized into retinoids and/or kept as a retinylester.[6] As a receptor, after holo-RBP is bound, STRA6 activates the JAK/STAT pathway, resulting in the activation of transcription factor, STAT5. These two functions—retinol transporter and cytokine receptor—while using different pathways, are processes that depend on each other.[7]
^Blaner WS (March 2007). "STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens". Cell Metabolism. 5 (3): 164–6. doi:10.1016/j.cmet.2007.02.006. PMID 17339024.
^Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N (August 2012). "Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6". Molecular and Cellular Biology. 32 (15): 3164–75. doi:10.1128/MCB.00505-12. PMC 3434520. PMID 22665496.
^Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, Habib S, Tosha C, Radu RA, Ghyselinck NB, Nusinowitz S, Bok D (May 2012). "Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6". Investigative Ophthalmology & Visual Science. 53 (6): 3027–39. doi:10.1167/iovs.11-8476. PMC 3378086. PMID 22467576.
^Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N (August 2012). "Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6". Molecular and Cellular Biology. 32 (15): 3164–75. doi:10.1128/MCB.00505-12. PMC 3434520. PMID 22665496.
^Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H (February 2007). "A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A". Science. 315 (5813): 820–5. Bibcode:2007Sci...315..820K. doi:10.1126/science.1136244. PMID 17255476. S2CID 25258551.
^Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N (August 2012). "Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6". Molecular and Cellular Biology. 32 (15): 3164–75. doi:10.1128/MCB.00505-12. PMC 3434520. PMID 22665496.
^Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N (August 2012). "Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6". Molecular and Cellular Biology. 32 (15): 3164–75. doi:10.1128/MCB.00505-12. PMC 3434520. PMID 22665496.
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