Unconventional protein secretion (known as ER/Golgi-independent protein secretion or nonclassical protein export[1] ) represents a manner in which the proteins are delivered to the surface of plasma membrane or extracellular matrix independent of the endoplasmic reticulum or Golgi apparatus.[2] This includes cytokines and mitogens with crucial function in complex processes such as inflammatory response or tumor-induced angiogenesis. Most of these proteins are involved in processes in higher eukaryotes, however an unconventional export mechanism was found in lower eukaryotes too.[3] Even proteins folded in their correct conformation can pass plasma membrane this way, unlike proteins transported via ER/Golgi pathway.[1] Two types of unconventional protein secretion are these: signal-peptid-containing proteins and cytoplasmatic and nuclear proteins that are missing an ER-signal peptide (1).[2]
^ abBackhaus R, Zehe C, Wegehingel S, Kehlenbach A, Schwappach B, Nickel W (April 2004). "Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding". Journal of Cell Science. 117 (Pt 9): 1727–1736. doi:10.1242/jcs.01027. PMID 15075234.
^ abNickel W, Rabouille C (February 2009). "Mechanisms of regulated unconventional protein secretion". Nature Reviews. Molecular Cell Biology. 10 (2): 148–155. doi:10.1038/nrm2617. PMID 19122676. S2CID 9824754.
^Nickel W (October 2010). "Pathways of unconventional protein secretion". Current Opinion in Biotechnology. 21 (5): 621–626. doi:10.1016/j.copbio.2010.06.004. PMID 20637599.
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Unconventionalproteinsecretion (known as ER/Golgi-independent proteinsecretion or nonclassical protein export ) represents a manner in which the proteins...
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