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Heat shock protein 47 information


SERPINH1
Identifiers
AliasesSERPINH1, AsTP3, CBP1, CBP2, HSP47, OI10, PIG14, PPROM, RA-A47, SERPINH2, gp46, serpin family H member 1
External IDsOMIM: 600943; MGI: 88283; HomoloGene: 20331; GeneCards: SERPINH1; OMA:SERPINH1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001207014
NM_001235

NM_001111043
NM_001111044
NM_009825
NM_001285776

RefSeq (protein)

NP_001193943
NP_001226

NP_001104513
NP_001104514
NP_001272705
NP_033955

Location (UCSC)Chr 11: 75.56 – 75.57 MbChr 7: 98.99 – 99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen.[5][6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149257 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070436 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)".
  6. ^ Dafforn TR, Della M, Miller AD (December 2001). "The molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesis". The Journal of Biological Chemistry. 276 (52): 49310–9. doi:10.1074/jbc.M108896200. PMID 11592970.

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Heat shock protein 47

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temperatures, heat-shock proteins, including chaperones and proteases are rapidly induced to protect against the denaturation of proteins within the bacteria...

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cytosolic proteins, will trimerize and enter the nucleus to upregulate the expression of heat shock proteins (HSPs) that will act as protein folding chaperones...

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abundant protein in egg white. Its exact function is unknown, but it is thought to be a storage protein for the developing foetus. Heat shock serpin 47 is a...

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a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury". Exp. Neurol. 184 (2): 636–47. doi:10.1016/S0014-4886(03)00343-1...

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competent cells, the length of time of heat shock, temperature of heat shock, incubation time after heat shock, growth medium used, pH and various additives...

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microsomal protein factions. Heat shock affected the abundance of HSPs depending on protein fraction and time of day. Without heat shock, nuclear membrane-bound...

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subunits (A and B) that are highly similar to the small (15-30kDa) heat shock proteins (sHsps), particularly in their C-terminal halves. The relationship...

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allowed to refold either by itself or with the help of heat shock proteins. Misfolded proteins can be eliminated through the ubiquitin-proteasome system...

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with an androgen, the androgen receptor is bound to heat shock proteins. These heat shock proteins are released upon androgen binding. Androgen binding...

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expression. KLF13 has been shown to interact with CREB-binding protein, Heat shock protein 47 and PCAF. Kruppel-like factors ENSG00000275746 GRCh38: Ensembl...

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