Type II hypersensitivity, in the Gell and Coombs classification of allergic reactions, is an antibody mediated process in which IgG and IgM antibodies are directed against antigens on cells (such as circulating red blood cells) or extracellular material (such as basement membrane). This subsequently leads to cell lysis, tissue damage or loss of function through mechanisms such as
complement activation via the classical complement pathway
Antibody-dependent cellular cytotoxicity or
anti-receptor activity.[1]
The activation of the complement system results in opsonization, the agglutination of red blood cells, cell lysis, and cell death.[2]
These reactions usually take between 2 and 24 hours to develop.[2]
^"Immunopathology".
^ abWarrington, Richard; Watson, Wade; Kim, Harold L.; Antonetti, Francesca Romana (10 November 2011). "An introduction to immunology and immunopathology". Allergy, Asthma, and Clinical Immunology. 7 (1): S1. doi:10.1186/1710-1492-7-S1-S1. ISSN 1710-1492. PMC 3245432. PMID 22165815.
and 26 Related for: Type II hypersensitivity information
TypeIIhypersensitivity, in the Gell and Coombs classification of allergic reactions, is an antibody mediated process in which IgG and IgM antibodies...
practice. Type I hypersensitivityTypeIIhypersensitivityType IV hypersensitivity Usman, Norina; Annamaraju, Pavan (2021), "Type III Hypersensitivity Reaction"...
Hypersensitivity (also called hypersensitivity reaction or intolerance) is an abnormal physiological condition in which there is an undesirable and adverse...
Type I hypersensitivity (or immediate hypersensitivity), in the Gell and Coombs classification of allergic reactions, is an allergic reaction provoked...
between the epidermal and dermal skin layers. It is classified as a typeIIhypersensitivity reaction, which involves formation of anti-hemidesmosome antibodies...
the Greek word pemphix, meaning blister. It is classified as a typeIIhypersensitivity reaction in which antibodies are formed against desmosomes, components...
inappropriately producing thyroid-stimulating immunoglobulin (IgG; typeIIhypersensitivity). Lymphocytes react not only against thyroid receptors, but also...
non-collagenous domain of type IV collagen. T cells are also implicated, though it is generally considered a typeIIhypersensitivity reaction. The diagnosis...
Type 2 or TypeII may refer to: TypeII, a Japanese submachine gun Type 2 12 cm Mortar, a Japanese weapon Type 2 20 mm AA machine cannon, a Japanese weapon...
pyogenes and multiple cardiac proteins can cause a life-threatening typeIIhypersensitivity reaction. Usually, self reactive B cells remain anergic in the...
four classes (Type I – IV) based on the mechanisms involved and the time course of the hypersensitive reaction. Type I hypersensitivity is an immediate...
mutilation Type 1 personality Type I hypersensitivity (or immediate hypersensitivity), an allergic reaction Type 1 diesel locomotives US F1 Type 1, 2010...
although direct alterations by cytokines, platelet adhesion, and a typeIIhypersensitivity reaction similarly have been implicated. Increased endothelin and...
of extended periods of exposure to cigarette smoke. Hypersensitivity pneumonitis Almost any type of lung tumor or lung cancer can compress the alveoli...
to, a hypersensitivity response occurs. Hypersensitivity is believed to be the cause of allergy and some auto-immune disease. Hypersensitivity reactions...
or an absolute increase in glomerular filtration rate (GFR). Most young Type 1 diabetic patients experience glomerular hyperfiltration, a typical functional...
it, e.g. the anticonvulsant hypersensitivity syndrome, allopurinol hypersensitivity syndrome, and dapsone hypersensitivity syndrome. In 1996, however,...
during menstruation.[citation needed] Pathogenically, it is a typeIIhypersensitivity reaction where circulating complement-fixing IgG antibodies bind...
release pro-allergic mediators (e.g. histamine); b) Type I, TypeII, and Type III hypersensitivity reactions of the adaptive immune system mediated by...
A tree nut allergy is a hypersensitivity to dietary substances from tree nuts and edible tree seeds causing an overreaction of the immune system which...
asthma are more likely to be severely affected. It is due to a type I hypersensitivity reaction of the immune system in susceptible individuals. The allergy...
although contact with the allergen or irritant must occur before the hypersensitivity reaction can develop (characteristically after re-exposure). Maternal...
prednisone will be prescribed to prevent a possible late phase Type I hypersensitivity reaction. Severe allergic reactions (anaphalaxis) may require treatment...
prednisone will be prescribed to prevent a possible late-phase type I hypersensitivity reaction. Severe allergic reactions (anaphylaxis) may require treatment...
Global Information