Tubulin GTPase (EC 3.6.5.6) is an enzyme with systematic name GTP phosphohydrolase (microtubule-releasing).[1][2][3] This enzyme catalyses the following chemical reaction
GTP + H2O GDP + phosphate
This enzyme participates in tubulin folding and division plane formation.
^Yu XC, Margolin W (September 1997). "Ca2+-mediated GTP-dependent dynamic assembly of bacterial cell division protein FtsZ into asters and polymer networks in vitro". The EMBO Journal. 16 (17): 5455–63. doi:10.1093/emboj/16.17.5455. PMC 1170176. PMID 9312004.
^Tian G, Bhamidipati A, Cowan NJ, Lewis SA (August 1999). "Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer". The Journal of Biological Chemistry. 274 (34): 24054–8. doi:10.1074/jbc.274.34.24054. PMID 10446175.
^Roychowdhury S, Panda D, Wilson L, Rasenick MM (May 1999). "G protein alpha subunits activate tubulin GTPase and modulate microtubule polymerization dynamics". The Journal of Biological Chemistry. 274 (19): 13485–90. doi:10.1074/jbc.274.19.13485. PMID 10224115.
TubulinGTPase (EC 3.6.5.6) is an enzyme with systematic name GTP phosphohydrolase (microtubule-releasing). This enzyme catalyses the following chemical...
"Tubulin and FtsZ form a distinct family of GTPases". Nat. Struct. Biol. 5 (6): 451–8. doi:10.1038/nsb0698-451. PMID 9628483. S2CID 5945125. GTPase at...
be related to tubulin. Tubulin is characterized by the evolutionarily conserved Tubulin/FtsZ family, GTPase protein domain. This GTPase protein domain...
Tubulin/FtsZ family, GTPase domain is an evolutionary conserved protein domain. This domain is found in all tubulin chains, as well as the bacterial FtsZ...
Rho GTPase activating protein 21 is a protein that in humans is encoded by the ARHGAP21 gene. ARHGAP21 functions preferentially as a GTPase-activating...
X-linked retinitis pigmentosa GTPase regulator is a GTPase-binding protein that in humans is encoded by the RPGR gene. The gene is located on the X-chromosome...
post-translational modification of proteins, for example, histones, p53, and tubulins. Among these proteins, chromatin proteins and metabolic enzymes are highly...
Tubulin beta chain is a protein that in humans is encoded by the TUBB gene. TUBB has been shown to interact with NCOA6 and SYT9. Tubulin ENSG00000232421...
Tubulin beta-2A chain is a protein that in humans is encoded by the TUBB2A gene. GRCh38: Ensembl release 89: ENSG00000137267 – Ensembl, May 2017 GRCm38:...
Tubulin, epsilon 1 is a protein in humans that is encoded by the TUBE1 gene. This gene encodes a member of the tubulin superfamily. This protein localizes...
where it is converted to guanosine diphosphate (GDP) through the action of GTPases. GTP is involved in energy transfer within the cell. For instance, a GTP...
Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene. This gene encodes a member of the tubulin superfamily. The encoded protein localizes...
Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins...
Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene. Microtubules of the eukaryotic cytoskeleton perform essential and diverse...
Kontani K, Katada T (September 2004). "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation". Journal...
homologs of tubulin/FtsZ seem to have conserved the ability to polymerize into filaments. FtsZ has the ability to bind to GTP and also exhibits a GTPase domain...
Nogales E, Downing KH, Amos LA, Löwe J (June 1998). "Tubulin and FtsZ form a distinct family of GTPases". Nature Structural Biology. 5 (6): 451–8. doi:10...
dynamics. γ-tubulin is a specialized tubulin variant that assembles into a ring complex called γ-TuRC which nucleates polymerization of α/β tubulin heterodimers...
Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene. Cofactor D is one of four proteins (cofactors A, D, E, and C) involved...
stress response and apoptosis. The FtsZ protein (a homologue to eukaryotic tubulin), found in many bacteria and some archaea, plays a role in mitochondrial...
Global Information