kif1a head-microtubule complex structure in atp-form
Identifiers
Symbol
Tubulin
Pfam
PF00091
Pfam clan
CL0442
InterPro
IPR003008
PROSITE
PDOC00201
SCOP2
1tub / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Tubulin
kif1a head-microtubule complex structure in atp-form
Identifiers
Symbol
Tubulin
Pfam
PF00091
Pfam clan
CL0442
InterPro
IPR003008
PROSITE
PDOC00201
SCOP2
1tub / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Tubulin/FtsZ family, GTPase domain is an evolutionary conserved protein domain.
This domain is found in all tubulin chains,[1] as well as the bacterial FtsZ family of proteins.[2] These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases,[3] this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.
^Nogales E, Wolf SG, Downing KH (January 1998). "Structure of the alpha beta tubulin dimer by electron crystallography". Nature. 391 (6663): 199–203. doi:10.1038/34465. PMID 9428769. S2CID 4412367.
^Löwe J, Amos LA (January 1998). "Crystal structure of the bacterial cell-division protein FtsZ". Nature. 391 (6663): 203–6. doi:10.1038/34472. PMID 9428770. S2CID 4330857.
^Nogales E, Downing KH, Amos LA, Löwe J (June 1998). "Tubulin and FtsZ form a distinct family of GTPases". Nat. Struct. Biol. 5 (6): 451–8. doi:10.1038/nsb0698-451. PMID 9628483. S2CID 5945125.
Tubulin/FtsZ family, GTPase domain is an evolutionary conserved protein domain. This domain is found in all tubulin chains, as well as the bacterial FtsZ...
related to tubulin. Tubulin is characterized by the evolutionarily conserved Tubulin/FtsZ family, GTPase protein domain. This GTPase protein domain is found...
A mitotic inhibitor, microtubule inhibitor, or tubulin inhibitor, is a drug that inhibits mitosis, or cell division, and is used in treating cancer, gout...
intracellular tubules, these proteins utilize a distinct tubulindomain that is unrelated to the G domain used by signaling GTPases. There are also GTP-hydrolyzing...
Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long...
involved in movement, feeding, and sensation. They are composed mainly of tubulin, and are entirely distinct from prokaryotic flagella. They are supported...
stathmin-like domain (SLD). When stathmin sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization...
third type of tubulin, γ-tubulin, which is distinct from the α and β subunits that compose the microtubules themselves. The γ-tubulin combines with several...
neurons. Neurotubules are undivided hollow cylinders that are made up of tubulin protein polymers and arrays parallel to the plasma membrane in neurons...
Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene. Microtubules of the eukaryotic cytoskeleton perform essential and diverse...
Tubulin beta chain is a protein that in humans is encoded by the TUBB gene. TUBB has been shown to interact with NCOA6 and SYT9. Tubulin ENSG00000232421...
post-translational modification of proteins, for example, histones, p53, and tubulins. Among these proteins, chromatin proteins and metabolic enzymes are highly...
Merdes A (May 2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules"....
Tubulin beta-2A chain is a protein that in humans is encoded by the TUBB2A gene. GRCh38: Ensembl release 89: ENSG00000137267 – Ensembl, May 2017 GRCm38:...
protein contains an N-terminal misato segment II myosin-like domain and a central tubulindomain. GRCh38: Ensembl release 89: ENSG00000125459 – Ensembl, May...
classes. Tubulin-like, actin-like, Walker A cytoskeletal ATPases (WACA-proteins), and intermediate filaments. Tubulin-like proteins are tubulin in eukaryotes...
Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene. TUBA1B has been shown to interact with PIK3R1. Antibodies against tubulin...
"Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding". Structure. 15 (3): 355–362...
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