TPM2 information

TPM2
Identifiers
Aliases	TPM2, AMCD1, DA1, DA2B, HEL-S-273, NEM4, TMSB, tropomyosin 2 (beta), tropomyosin 2, DA2B4
External IDs	OMIM: 190990; MGI: 98810; HomoloGene: 134045; GeneCards: TPM2; OMA:TPM2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,690,056 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,523,765 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; popliteal artery; ; tibial arteries; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; gastric mucosa; ; right coronary artery; ; ascending aorta; ; Skeletal muscle tissue of biceps brachii; ; Descending thoracic aorta;
	Top expressed in
	intercostal muscle; ; tunica media of zone of aorta; ; ascending aorta; ; ankle; ; sternocleidomastoid muscle; ; soleus muscle; ; muscle of thigh; ; temporal muscle; ; digastric muscle; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; structural constituent of muscle; identical protein binding; protein homodimerization activity; protein heterodimerization activity; actin filament binding;
Cellular component	cytoplasm; muscle thin filament tropomyosin; cytosol; cytoskeleton; actin filament; actin cytoskeleton;
Biological process	regulation of ATP-dependent activity; muscle filament sliding; muscle contraction; actin filament organization;
	Sources:Amigo / QuickGO
Orthologs
	7169
	22004
	ENSG00000198467
	ENSMUSG00000028464
	P07951
	P58774
	NM_001145822; NM_001301226; NM_001301227; NM_003289; NM_213674
	NM_001277875; NM_001277876; NM_009416
	NP_001288155; NP_001288156; NP_003280; NP_998839
	NP_001264804; NP_001264805; NP_033442
	Wikidata
View/Edit Human	View/Edit Mouse

β-Tropomyosin, also known as tropomyosin beta chain is a protein that in humans is encoded by the TPM2 gene.^[5]^[6] β-tropomyosin is striated muscle-specific coiled coil dimer that functions to stabilize actin filaments and regulate muscle contraction.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198467 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028464 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hunt CC, Eyre HJ, Akkari PA, Meredith C, Dorosz SM, Wilton SD, Callen DF, Laing NG, Baker E (Aug 1995). "Assignment of the human beta tropomyosin gene (TPM2) to band 9p13 by fluorescence in situ hybridisation". Cytogenetics and Cell Genetics. 71 (1): 94–5. doi:10.1159/000134070. PMID 7606936.
^ "Entrez Gene: TPM2 tropomyosin 2 (beta)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198467 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028464 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7606936-5] Hunt CC, Eyre HJ, Akkari PA, Meredith C, Dorosz SM, Wilton SD, Callen DF, Laing NG, Baker E (Aug 1995). "Assignment of the human beta tropomyosin gene (TPM2) to band 9p13 by fluorescence in situ hybridisation". Cytogenetics and Cell Genetics. 71 (1): 94–5. doi:10.1159/000134070. PMID 7606936.

[entrez-6] "Entrez Gene: TPM2 tropomyosin 2 (beta)".

TPM2 information

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