Triflusal information

Triflusal
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	B01AC18 (WHO) ;
Identifiers
	IUPAC name 2-acetyloxy-4-(trifluoromethyl)benzoic acid;
CAS Number	322-79-2 ;
PubChem CID	9458;
DrugBank	DB08814 ;
ChemSpider	9086 ;
UNII	1Z0YFI05OO;
ChEMBL	ChEMBL1332032 ;
CompTox Dashboard (EPA)	DTXSID8045305 ;
ECHA InfoCard	100.005.726
Chemical and physical data
Formula	C10H7F3O4
Molar mass	248.157 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)Oc1cc(ccc1C(=O)O)C(F)(F)F;
	InChI InChI=1S/C10H7F3O4/c1-5(14)17-8-4-6(10(11,12)13)2-3-7(8)9(15)16/h2-4H,1H3,(H,15,16) ; Key:RMWVZGDJPAKBDE-UHFFFAOYSA-N ;

Triflusal is a platelet aggregation inhibitor that was discovered and developed in the Uriach Laboratories, and commercialised in Spain since 1981. Currently, it is available in 25 countries in Europe, Asia, Africa and America. It is a derivative of acetylsalicylic acid (ASA; Aspirin) in which a hydrogen atom on the benzene ring has been replaced by a trifluoromethyl group. Trade names include Disgren, Grendis, Aflen and Triflux.^[1]

Triflusal has multiple mechanisms of action that contribute to the effect of the drug. It is a COX-1 inhibitor. It also inhibits the activation of nuclear factor k-B, which in turn regulates the expression of the mRNA of the vascular cell adhesion molecule-1 needed for platelet aggregation. Additionally, Triflusal preserves vascular prostacyclin which yields an anti-platelet effect. Triflusal also blocks phosphodiesterase, increasing cAMP concentration as well as can increase nitric oxide synthesis in neutrophils.

^ Murdoch D, Plosker GL (2006). "Triflusal: a review of its use in cerebral infarction and myocardial infarction, and as thromboprophylaxis in atrial fibrillation". Drugs. 66 (5): 671–92. doi:10.2165/00003495-200666050-00009. PMID 16620146. S2CID 195684205.

[pmid16620146-1] Murdoch D, Plosker GL (2006). "Triflusal: a review of its use in cerebral infarction and myocardial infarction, and as thromboprophylaxis in atrial fibrillation". Drugs. 66 (5): 671–92. doi:10.2165/00003495-200666050-00009. PMID 16620146. S2CID 195684205.

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