Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration in vivo is much higher than other anions.[1] Several families of voltage-gated channels and ligand-gated channels (e.g., the CaCC families) have been characterized in humans.
Voltage-gated chloride channels perform numerous crucial physiological and cellular functions, such as controlling pH, volume homeostasis, transporting organic solutes, regulating cell migration, proliferation, and differentiation. Based on sequence homology the chloride channels can be subdivided into a number of groups.
^Jentsch TJ, Stein V, Weinreich F, Zdebik AA (April 2002). "Molecular structure and physiological function of chloride channels". Physiological Reviews. 82 (2): 503–68. doi:10.1152/physrev.00029.2001. PMID 11917096.
Chloridechannels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named...
Chloridechannel openers refer to a specific category of drugs designed to modulate chloridechannels in the human body. Chloridechannels are anion-selective...
however chloride is the most abundant anion, and hence they are known as chloridechannels. Potassium channels Voltage-gated potassium channels e.g., Kvs...
A chloridechannel blocker is a type of drug which inhibits the transmission of ions (Cl−) through chloridechannels. Niflumic acid is a chloride channel...
have mutations in the chloride gene but rather in the alpha-subunit of the voltage gated sodium channel (SCN4A). Like chloridechannel mutations, patients...
sodium chloride (NaCl). 4-propylphenyl 2-furoate is a compound that was discovered to activate proteolyzed ENaC. Studies show that the ENaC channel is permeable...
caused by an inherited disorder of a chloridechannel in the muscles of the skeleton (skeletal muscle chloridechannel 1, CLCN1). Congenital myotonia can...
Other examples of ionic chlorides are sodium chloride NaCl, calcium chloride CaCl2 and ammonium chloride [NH4]Cl. The chloride is also a neutral chlorine...
inhibit the conductance of chloridechannels. Ingestion of lethal volumes of Cltx results in paralysis through this ion channel disruption. Similar to botulinum...
Solutions of polyethylene glycol and electrolytes (sodium chloride, sodium bicarbonate, potassium chloride, and sometimes sodium sulfate) are used for whole bowel...
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily...
The CLCN5 gene encodes the chloridechannel Cl-/H+ exchanger ClC-5. ClC-5 is mainly expressed in the kidney, in particular in proximal tubules where it...
mostly by enhancing the effects of glutamate at the glutamate-gated chloridechannel that is specific to protostome invertebrates, with minor effects on...
channel opener Sodium channel: see also Sodium channel blocker, Sodium channel opener Chloridechannel: see also Chloridechannel blocker, Chloride channel...
concentration of chloride that is excreted in sweat. It is used to screen for cystic fibrosis (CF). Due to defective chloridechannels (CFTR), the concentration...
passage of chloride ions. A mutation in the CFTR gene can impair the normal function of chloridechannels, leading to abnormal transport of chloride ions and...
ion channel protein that conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations of the CFTR gene affecting anion channel function...
Chloridechannel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene. Chloridechannel Kb (CLCNKB) is a member of the...
gamma-aminobutyric acid) and other ligand-gated chloridechannels. Isoxazolines, among the chloridechannel modulators, bind to a distinct and unique target...
magnesium chloride, magnesium lactate, and magnesium aspartate, may increase or enhance the effects of calcium channel blockade. N-type calcium channels are...
even death, as might be expected from potentiation of inhibitory chloridechannels. Since drugs that inhibit the enzyme CYP3A4 often also inhibit P-glycoprotein...
electric current in the heart that flows through the HCN channel or pacemaker channel. Such channels are important parts of the electrical conduction system...
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