Arsenite resistance (Ars) efflux pumps of bacteria may consist of two proteins, ArsB (TC# 2.A.45.1.1; the integral membrane constituent with twelve transmembrane spanners) and ArsA (TC# 3.A.4.1.1; the ATP-hydrolyzing, transport energizing subunit, as for the chromosomally-encoded E. coli system), or of one protein (just the ArsB integral membrane protein of the plasmid-encoded Staphylococcus system).[1][2][3] ArsA proteins have two ATP binding domains and probably arose by a tandem gene duplication event. ArsB proteins all possess twelve transmembrane spanners and may also have arisen by a tandem gene duplication event. Structurally, the Ars pumps resemble ABC-type efflux pumps, but there is no significant sequence similarity between the Ars and ABC pumps. When only ArsB is present, the system operates by a pmf-dependent mechanism, and consequently belongs in TC subclass 2.A (i.e.,TC# 2.A.45). When ArsA is also present, ATP hydrolysis drives efflux, and consequently the system belongs in TC subclass 3.A (i.e., TC# 3.A.4). ArsB therefore appears twice in the TC system (ArsB and ArsAB) but ArsA appears only once. These pumps actively expel both arsenite and antimonite.[1][2][3][4]
^ abRensing C, Ghosh M, Rosen BP (October 1999). "Families of soft-metal-ion-transporting ATPases". Journal of Bacteriology. 181 (19): 5891–7. doi:10.1128/JB.181.19.5891-5897.1999. PMC 103614. PMID 10498699.
^ abRosen BP (1999-01-01). "The role of efflux in bacterial resistance to soft metals and metalloids". Essays in Biochemistry. 34: 1–15. doi:10.1042/bse0340001. PMID 10730185.
^ abXu C, Zhou T, Kuroda M, Rosen BP (January 1998). "Metalloid resistance mechanisms in prokaryotes". Journal of Biochemistry. 123 (1): 16–23. doi:10.1093/oxfordjournals.jbchem.a021904. PMID 9504403.
the TC system (ArsBandArsAB) but ArsA appears only once. These pumps actively expel both arsenite and antimonite. Homologues of ArsB are found in Gram-negative...
function either as secondary carriers or as primary active transporters, similarly to the ArsBandArsAB families. In the latter case ATP hydrolysis again energizes...
psoseses a heme d. Cytochormes bo oxidase is one of the main electron transporters during the elctron transport chain of aerobic respiration. It has the...
Preserver (ARS-8) USS Shackle (ARS-9) USS Protector (ARS-14) USS Cable (ARS-19) USS Chain (ARS-20), later T-AGOR-17 USS Curb (ARS-21) USS Current (ARS-22) USS...
the conversion of nitrate to nitrite. Certain nitrite transporters also transport bicarbonate, and elevated CO2 has been shown to suppress nitrite transport...
between Montreux and Saanen and the transport of standard gauge wagons on transporter bogies between Zweisimmen and stations to Rougemont and Lenk. By the...
catalyzed. Metal micronutrients are taken up into organisms by specific transportersand bind to storage proteins such as ferritin or metallothionein when not...
and UGT1A6. Multidrug resistance-associated proteins (Mrps) are important membrane transporters that efflux various compounds from various organs and...
of VMware, Virtual PC virtual machines and Boot Camp partitions Improved network, hard drive andTransporter performance Windows program Spotlight integration...
and Chemical Toxicology. 49 (2): 356–62. doi:10.1016/j.fct.2010.11.008. PMID 21078358. Batista R, Nunes B, Carmo M, Cardoso C, José HS, de Almeida AB...
(February 2018). "ZIP9, a novel membrane androgen receptor and zinc transporter protein". General and Comparative Endocrinology. 257: 130–136. doi:10.1016/j...
transporters or endocytosis [32,33]. Proper entry into the cell and subsequent contact with the exact target lead to better therapeutic effects and reduce...
classification number, top assisted speed, and motor wattage of the bike. Transport portal Outline of cycling Personal transporter (International regulation section)...
al. 2009 find Lr34 to be an ABC transporter, and conclude that this is the probable reason for its effectiveness and the reason that it produces a 'slow...
drug is composed of a single monoclonal antibody (mAb) and was initially isolated from immortalized B-cells that were obtained from a survivor of the 1995...
a potent antagonist of ZIP9, a membrane androgen receptor (mAR) and zinc transporter protein, with an IC50 of 66.3 nM (relative to Kd = 17.9 nM for testosterone)...
engines, and two stage adapters. Ground systems located at Kennedy where the launches will take place—the Vehicle Assembly Building, Crawler-Transporter, Mobile...
groups of Complexes III and IV). The architecture of the hydrophobic region of complex I shows multiple proton transporters that are mechanically interlinked...
cholesterol". Ars Technica. 15 November 2023. Retrieved 15 November 2023. "VERVE-101: CRISPR-Based Gene Editing Therapy Shows Promise in Reducing LDL-C and PCSK9...
gene are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein plays...
Vito/Viano, Peugeot Expert, Renault Trafic and Volkswagen Transporter, the Custom is offered in two body lengths and two roof heights. Offered in most worldwide...
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