In molecular biology, Toxic Small RNA(tsRNA, not to be confused with tRNA-derived small RNA) is a family of trans-encoded small non-coding RNA found exclusively in intergenic regions of Betaproteobacteria.[1][2] Several paralogous loci may encode similar (but not identical) tsRNAs in each coding genome. Typically, each species of Burkholderia has 3-5 homologous tsRNAs.[3] Experiments with four species of the Burkholderia lineage showed conserved and constitutive expression of tsRNAs in logarithmic growth phases.[4]
^Dobrzanski T, Pobre V, Moreno LF, Barbosa HC, Monteiro RA, de Oliveira Pedrosa F, et al. (February 2020). "In silico prediction and expression profile analysis of small non-coding RNAs in Herbaspirillum seropedicae SmR1". BMC Genomics. 21 (1): 134. doi:10.1186/s12864-019-6402-x. PMC 7011215. PMID 32039705.
^Kalvari I, Argasinska J, Quinones-Olvera N, Nawrocki EP, Rivas E, Eddy SR, et al. (January 2018). "Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families". Nucleic Acids Research. 46 (D1): D335–D342. doi:10.1093/nar/gkx1038. PMC 5753348. PMID 29112718.
^Sass A, Kiekens S, Coenye T (November 2017). "Identification of small RNAs abundant in Burkholderia cenocepacia biofilms reveal putative regulators with a potential role in carbon and iron metabolism". Scientific Reports. 7 (1): 15665. Bibcode:2017NatSR...715665S. doi:10.1038/s41598-017-15818-3. PMC 5688073. PMID 29142288.
^Kimelman A, Levy A, Sberro H, Kidron S, Leavitt A, Amitai G, et al. (April 2012). "A vast collection of microbial genes that are toxic to bacteria". Genome Research. 22 (4): 802–9. doi:10.1101/gr.133850.111. PMC 3317161. PMID 22300632.
molecular biology, ToxicSmallRNA (tsRNA, not to be confused with tRNA-derived smallRNA) is a family of trans-encoded small non-coding RNA found exclusively...
TsRNA can stand for: ToxicSmallRNA tRNA-derived smallRNA This disambiguation page lists articles associated with the title TsRNA. If an internal link...
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules...
Ribosomal RNA is transcribed from ribosomal DNA (rDNA) and then bound to ribosomal proteins to form small and large ribosome subunits. rRNA is the physical...
ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded,...
classes of smallRNA have currently been identified, namely: small interfering RNA (siRNA), microRNA (miRNA), and piwi-interacting RNA (piRNA). siRNAs act in...
in 50 copies or more within the genome of E. coli. Sib RNA regulates the expression of a toxic protein in a type I toxin-antitoxin system similar to that...
An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules...
toxin-antitoxin systems, the gene expression of a toxic protein is regulated by a small non-coding RNA. Type I toxin-antitoxin loci are frequently found...
of smallRNAs located in intergenic regions of its genome. The presence of at least 55 of these has been verified experimentally. 275 potential sRNA-encoding...
non-coding RNAs (e.g., snRNAs, snoRNAs or long non-coding RNAs). RNA polymerase III transcribes 5S rRNA, transfer RNA (tRNA) genes, and some small non-coding...
a refrigerant R32: Contact with acids liberates very toxic gas, a risk phrase Small nucleolar RNA R32/R81/Z41 This disambiguation page lists articles associated...
inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, which is...
ribose on an intact phosphodiester RNA backbone. Ricin is very toxic if inhaled, injected, or ingested. It can also be toxic if dust contacts the eyes or if...
change the regulation of gene expression; produce a toxicRNA, or lead to production of a toxic protein. In general, the larger the expansion the faster...
a Formula One car Rubik R-24 Bibic, a Hungarian training glider Small nucleolar RNA R24 USS R-24 (SS-101), a submarine of the United States Navy This...
DNA alterations that result in incorrect RNA sequences and result in mistranslated proteins that have a toxic physiological effect. Cell uptake/internalisation...
the editosome. Editing of ApoB mRNA in humans is tissue regulated, with ApoB48 being the main ApoB protein of the small intestine in humans. It occurs...
approach are the toxicity of the transfection for cells and potential "off-target" effects on the expression of other genes/proteins. RNA can be purified...
the toxic effects. The major toxic mechanism is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and...
biochemistry. In sufficient concentration it will cause protein, DNA and RNA to precipitate out of solution. The sodium salt of trichloroacetic acid is...
Global Information