Light micrograph of focal segmental glomerulosclerosis, hilar variant. Kidney biopsy. PAS stain.
Specialty
Nephrology
Focal segmental glomerulosclerosis (FSGS) is a histopathologic finding of scarring (sclerosis) of glomeruli and damage to renal podocytes.[2][3] This process damages the filtration function of the kidney, resulting in protein presence in the urine due to protein loss.[3] FSGS is a leading cause of excess protein loss—nephrotic syndrome—in children and adults.[4] Signs and symptoms include proteinuria and edema.[2][5] Kidney failure is a common long-term complication of the disease.[5][6] FSGS can be classified as primary, secondary, or genetic, depending on whether a particular toxic or pathologic stressor or genetic predisposition can be identified as the cause.[7][8][9] Diagnosis is established by renal biopsy,[2][10] and treatment consists of glucocorticoids and other immune-modulatory drugs.[11] Response to therapy is variable, with a significant portion of patients progressing to end-stage kidney failure.[5] An American epidemiological study 20 years ago demonstrated that FSGS is estimated to occur in 7 persons per million, with males and African-Americans at higher risk .[12][13][7]
^ ab"focal segmental glomerulosclerosis" at Dorland's Medical Dictionary.
^ abcRosenberg, Avi Z.; Kopp, Jeffrey B. (2017-03-07). "Focal Segmental Glomerulosclerosis". Clinical Journal of the American Society of Nephrology. 12 (3): 502–517. doi:10.2215/CJN.05960616. ISSN 1555-9041. PMC 5338705. PMID 28242845.
^ abD'Agati V. The many masks of focal segmental glomerulosclerosis. Kidney Int. 1994 Oct;46(4):1223–41. doi: 10.1038/ki.1994.388. PMID 7861720.
^Kitiyakara C, Eggers P, Kopp JB. Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. Am J Kidney Dis. 2004 Nov;44(5):815–25. PMID 15492947.
^ abcRydel JJ, Korbet SM, Borok RZ, Schwartz MM. Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment. Am J Kidney Dis. 1995 Apr;25(4):534–42. doi: 10.1016/0272-6386(95)90120-5. PMID 7702047.
^Korbet SM, Schwartz MM, Lewis EJ. Primary focal segmental glomerulosclerosis: clinical course and response to therapy. Am J Kidney Dis. 1994 Jun;23(6):773–83. doi: 10.1016/s0272-6386(12)80128-4. PMID 8203357.
^Haas M, Meehan SM, Karrison TG, Spargo BH. Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976–1979 and 1995–1997. Am J Kidney Dis. 1997 Nov;30(5):621–31. doi: 10.1016/s0272-6386(97)90485-6. PMID 9370176.
^Cite error: The named reference :6 was invoked but never defined (see the help page).
^Kiffel J, Rahimzada Y, Trachtman H. Focal segmental glomerulosclerosis and chronic kidney disease in pediatric patients. Adv Chronic Kidney Dis. 2011 Sep;18(5):332–8. doi: 10.1053/j.ackd.2011.03.005. PMID 21896374; PMCID: PMC3709971.
^Campbell KN, Tumlin JA. Protecting Podocytes: A Key Target for Therapy of Focal Segmental Glomerulosclerosis. Am J Nephrol. 2018;47 Suppl 1(Suppl 1):14–29. doi: 10.1159/000481634. Epub 2018 May 31. PMID 29852493; PMCID: PMC6589822.
^Tucker JK. Focal segmental glomerulosclerosis in African Americans. Am J Med Sci. 2002 Feb;323(2):90–3. doi: 10.1097/00000441-200202000-00006. PMID 11863085.
^Kitiyakara C, Kopp JB, Eggers P. Trends in the epidemiology of focal segmental glomerulosclerosis. Semin Nephrol. 2003 Mar;23(2):172–82. doi: 10.1053/snep.2003.50025. PMID 12704577.
and 24 Related for: Focal segmental glomerulosclerosis information
Focalsegmentalglomerulosclerosis (FSGS) is a histopathologic finding of scarring (sclerosis) of glomeruli and damage to renal podocytes. This process...
More specifically, glomerulosclerosis can refer to:[citation needed] Focalsegmentalglomerulosclerosis Nodular glomerulosclerosis (diabetic) Early stages...
chronic kidney disease.: 500 : 550 Focalsegmentalglomerulosclerosis is characterised by a sclerosis of segments of some glomeruli. It is likely to present...
shown to increase the risk of developing diseases such as FocalSegmentalGlomerulosclerosis(FSGS), Hypertension Attributed-End Stage Kidney Disease (ESKD)...
pressure. Causes include a number of kidney diseases such as focalsegmentalglomerulosclerosis, membranous nephropathy, and minimal change disease. It may...
percentage of all cases has not been established—for example, focalsegmentalglomerulosclerosis or ankylosing spondylitis; the majority of these cases are...
June 2014, Cole suffered kidney failure after developing focalsegmentalglomerulosclerosis. In April 2017, he underwent a kidney transplant. His nephew...
for the treatment of idiopathic pulmonary fibrosis (IPF), focalsegmentalglomerulosclerosis, and cancer (kidney cancer and melanoma). It binds to and...
bodybuilding's top tier. In 1999, Wheeler discovered that he had focalsegmentalglomerulosclerosis, a form of kidney disease. Despite press speculation as to...
second most common cause of nephrotic syndrome in adults, with focalsegmentalglomerulosclerosis (FSGS) recently becoming the most common. Most people will...
studies suggest galactose may have a role in treatment of focalsegmentalglomerulosclerosis (a kidney disease resulting in kidney failure and proteinuria)...
a railway station in Sussex, England Fluorosilicate glass Focalsegmentalglomerulosclerosis Free Spirit Gathering, an American Pagan and Pantheist event...
change disease, membranoproliferative glomerulonephritis, or focalsegmentalglomerulosclerosis. In adults, on the other hand, nephrotic syndrome is commonly...
(November 2009). "Molecular genetic analysis of podocyte genes in focalsegmentalglomerulosclerosis--a review". European Journal of Pediatrics. 168 (11): 1291–1304...
podocin gene NPHS2 can cause nephrotic syndrome, such as focalsegmentalglomerulosclerosis (FSGS) or minimal change disease (MCD). Symptoms may develop...
and dysmorphic features Epilepsy-telangiectasia syndrome Focalsegmentalglomerulosclerosis and neurodevelopmental syndrome Fontaine progeroid syndrome...
drug toxicity. Heroin and Pamidronate are known to cause focalsegmentalglomerulosclerosis Gold salts therapy can cause membranous nephropathy Penicillamine...
of tumors. Mutations in ACTN4 can cause the kidney disease focalsegmentalglomerulosclerosis (FSGS). Actin Muscle contraction Sjöblom B, Salmazo A, Djinović-Carugo...
awareness for kidney diseases, including Nephrotic Syndrome and FocalSegmentalGlomerulosclerosis (FSGS), conditions that his daughter was diagnosed with prior...
HIV-associated nephropathy (HIVAN), primary nonmonogenic forms of focalsegmentalglomerulosclerosis, and hypertension affiliated chronic kidney disease not attributed...
Thus, this could in certain circumstances be the case for focalsegmentalglomerulosclerosis after inhalational exposure: such a glomerulopathy with noteworthy...
fork-lift operator, and Edmonia Sue, a nurse practitioner. Due to focalsegmentalglomerulosclerosis, a kidney disease, and the corticosteroids and other medications...
Global Information
