Degree to which overt adverse effects of a drug can be tolerated by a patient
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Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient.[1] Tolerability of a particular drug can be discussed in a general sense, or it can be a quantifiable measurement as part of a clinical study. Usually, it is measured by the rate of "dropouts", or patients that forfeit participation in a study due to extreme adverse effects. Tolerability, however, is often relative to the severity of the medical condition a drug is designed to treat.[1] For instance, cancer patients may tolerate significant pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache, are less likely to.
As an example, tricyclic antidepressants (TCAs) are very poorly tolerated and often produce severe side effects including sedation, orthostatic hypotension, and anticholinergic effects, whereas newer antidepressants have far fewer adverse effects and are well tolerated.
Drug tolerability should not be confused with drug tolerance, which refers to subjects' reduced reaction to a drug following its repeated use.
^ abTon, Nu Thanh Huyen; Hartstra, Jan; Persiani, Stefano; Beckert, Michael. "Safety - Tolerability". PharmPK Discussion. David W.A. Bourne. Retrieved 13 November 2013.
Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient. Tolerability of a particular drug can be discussed...
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Tolerable daily intake (TDI) refers to the daily amount of a chemical that has been assessed safe for human being on long-term basis (usually whole lifetime)...
are preferred over other antidepressants due to their acceptability, tolerability, and superior reduction of symptoms in short-term trials. Long-term efficacy...
columnist and television writer. She wrote the weekly infographic "The Tolerability Index" for The A.V. Club for 10 years and was a writer for the US version...
firmly believed to be adequate for everyone in the demographic group. Tolerable upper intake levels (UL), to caution against excessive intake of nutrients...
consequences have been named as: Maximum tolerable period of disruption (MTPoD) Maximum tolerable downtime (MTD) Maximum tolerable outage (MTO) Maximum acceptable...
Tolerable weekly intake (TWI) estimates the amount per unit body weight of a potentially harmful substance or contaminant in food or water that can be...
couple of years. Other benefits include greater flexibility and better tolerability in those with significant heart disease. Complications may include infections...
Though poor at first, Philadelphia became an important trading center with tolerable living conditions by the 1750s. Benjamin Franklin, a leading citizen,...
RDA increases with age from 3 to 8 mg/day. As for safety, the IOM sets Tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient...
debate Catherine's technical status, whether as a regent or as a usurper, tolerable only during the minority of her son, Grand Duke Paul. Catherine was crowned...
proportion of individual prepackages having a negative error greater than the tolerable negative error shall be sufficiently small for batches of prepackages...
Samara M, Peter N, et al. (September 2019). "Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode...
European Union and the governments of several countries have established Tolerable upper intake levels (ULs) for those vitamins which have documented toxicity...
coumarin, a component of cinnamon, and confirmed a maximum recommended tolerable daily intake (TDI) of 0.1 mg of coumarin per kg of body weight. Coumarin...
effects. According to a 2013 meta-analysis of the comparative efficacy and tolerability of 15 antipsychotic drugs it was the most prone of the 15 for causing...
ISBN 9780849345647. Simons FE (May 1994). "H1-receptor antagonists. Comparative tolerability and safety". Drug Safety. 10 (5): 350–380. doi:10.2165/00002018-199410050-00002...
RC, Hellstrom WJ, Shabsigh R, et al. (September 2006). "Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis...
Lukić P, Locatelli I (February 2019). "Efficacy, Acceptability, and Tolerability of Lisdexamfetamine, Mixed Amphetamine Salts, Methylphenidate, and Modafinil...
C, Baumelou E, Bégaud B, et al. (September 1998). "Gastrointestinal tolerability of meloxicam compared to diclofenac in osteoarthritis patients. International...
reserving to the states ... the authority of training the militia ... A tolerable expertness in military movements is a business that requires time and...
Zachar in the sukkah. Males sleep in the sukkah, provided the weather is tolerable. If it rains, the requirement of eating and sleeping in the sukkah is...
sufficient information to establish EARs and RDAs. Countries establish tolerable upper intake levels, also referred to as upper limits (ULs), based on...
antidepressant of choice due to tentative evidence favoring its efficacy and tolerability. Evidence supporting an increased risk of major fetal malformations resulting...