Comparison of bicalutamide with other antiandrogens information
Comparison of the nonsteroidal antiandrogen (NSAA) bicalutamide with other antiandrogens reveals differences between the medications in terms of efficacy, tolerability, safety, and other parameters. Relative to the other first-generation NSAAs, flutamide and nilutamide, bicalutamide shows improved potency, efficacy, tolerability, and safety, and has largely replaced these medications in clinical practice. Compared to the second-generation NSAAs, enzalutamide and apalutamide, bicalutamide has inferior potency and efficacy but similar tolerability and safety and a lower propensity for drug interactions.
Relative to steroidal antiandrogens like cyproterone acetate and spironolactone, bicalutamide has better selectivity in its action, superior efficacy as an antagonist of the androgen receptor, and better tolerability. Bicalutamide also shows a better safety profile than cyproterone acetate. When used as a high-dosage monotherapy, bicalutamide shows slightly inferior effectiveness in the treatment of prostate cancer compared to castration and GnRH analogues but a different and potentially superior tolerability and safety profile. Unlike antigonadotropic antiandrogens like cyproterone acetate and GnRH analogues, bicalutamide does not suppress production of testosterone or estradiol and instead actually increases it[citation needed], which has an important involvement in the differential side-effect profiles of the medications.[citation needed]
and 27 Related for: Comparison of bicalutamide with other antiandrogens information
Comparisonof the nonsteroidal antiandrogen (NSAA) bicalutamidewithotherantiandrogens reveals differences between the medications in terms of efficacy...
Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer. It is typically...
enobosarm. Antiandrogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiprogestogens. Antiandrogens are used...
The medical uses ofbicalutamide, a nonsteroidal antiandrogen (NSAA), include the treatment of androgen-dependent conditions and hormone therapy to block...
a monotherapy, bicalutamide can induce breast development in males due to its estrogenic effects. Unlike other kinds ofantiandrogens, it may have less...
The side effects ofbicalutamide, a nonsteroidal antiandrogen (NSAA), including its frequent and rare side effects, have been well-studied and characterized...
and effective antiandrogen in comparison to first-generation NSAAs such as bicalutamide, flutamide, and nilutamide. Also, unlike with the first-generation...
from the addition of an antiandrogen, as antiandrogens can reduce or eliminate such symptoms. Steroidal antiandrogens are antiandrogens that resemble steroid...
data does not favor any one type of oral contraceptive over another. List of medications: Bicalutamide: A pure antiandrogen. It is effective similarly to...
first antiandrogen was discovered in the 1960s. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone...
leuprorelin and degarelix, nonsteroidal antiandrogens like flutamide and bicalutamide, the diuretic and steroidal antiandrogen spironolactone, the progestin medroxyprogesterone...
comparative risk of seizures and other central side effects. Apalutamide has 5- to 10-fold greater affinity for the AR than bicalutamide, a first-generation...
small risk of hepatotoxicity in comparison. Aside from its risk of liver toxicity and besides other nonsteroidal antiandrogens, it has been said that flutamide...
treatment of conditions such as muscle wasting, osteoporosis, and benign prostatic hypertrophy (BPH), using the nonsteroidal antiandrogenbicalutamide as a...
putrescine for stabilizing their DNA. Antiandrogens, including spironolactone, cyproterone acetate, flutamide, bicalutamide, and finasteride, can be used to...
the case of most other AAS, which are either potentiated by 5α-reductase in such tissues or are not metabolized by 5α-reductase. Antiandrogens like cyproterone...
published cases of hepatotoxicity for antiandrogens totaled 46 for flutamide, 21 for cyproterone acetate, 4 for nilutamide, and 1 for bicalutamide. Similarly...
nonsteroidal antiandrogenbicalutamide is an alternative option to flutamide with improved safety. The combination of spironolactone with a birth control...
lower affinity for the AR in comparison. In accordance, it has relatively high affinity for the AR among steroidal antiandrogens, and almost completely inhibits...
lipid changes have also been seen withotherantiandrogens, for instance spironolactone and bicalutamide, and with androgenic medications. The Women's...
6% of placebo), and 1.9% had enlarged breasts (vs 1% of placebo). Exposure during pregnancy is specifically contraindicated because antiandrogens such...
Conversely, CPA is a much more potent antiandrogen than nonsteroidal antiandrogens like flutamide and bicalutamide in gonadally intact male animals, which...
Wang M, Jiang Y, Tang Y, Wang H (August 2018). "Comparisonof the Microstructures and Properties of Different Microcannulas for Hyaluronic Acid Injection"...
(1990). "A comparisonof cocaine, lidocaine with epinephrine, and oxymetazoline for prevention of epistaxis on nasotracheal intubation". Journal of Clinical...
conventional antiandrogens like bicalutamide and enzalutamide. The first SARMs were arylpropionamides derived from the nonsteroidal antiandrogenbicalutamide. They...
the first pure antiandrogen to be developed, withother closely following examples of this class including the steroidal antiandrogens benorterone and...
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