positive regulation of cytokine-mediated signaling pathway
positive regulation of cell population proliferation
positive regulation of chemokine production
positive regulation of interleukin-10 production
positive regulation of interleukin-13 production
positive regulation of interleukin-5 production
positive regulation of interleukin-6 production
positive regulation of mast cell activation
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of apoptotic process
positive regulation of inflammatory response
defense response to Gram-negative bacterium
defense response to fungus
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of chemokine (C-C motif) ligand 1 production
positive regulation of granulocyte colony-stimulating factor production
positive regulation of receptor signaling pathway via STAT
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
85480
53603
Ensembl
ENSG00000145777
ENSMUSG00000024379
UniProt
Q969D9
Q9JIE6
RefSeq (mRNA)
NM_033035 NM_138551
NM_021367
RefSeq (protein)
NP_149024 NP_612561
NP_067342
Location (UCSC)
Chr 5: 111.07 – 111.08 Mb
Chr 18: 32.95 – 32.95 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-2-like cytokine, alarmin, and growth factor involved in numerous physiological and pathological processes, primarily those of the immune system.[5][6] It shares a common ancestor with IL-7.[7]
Originally appreciated for its role in immune cell proliferation and development, and then for its pivotal role in type 2 immune responses, TSLP is now known to be involved in other types of immune responses, autoimmune disease, and certain cancers.[5][6][8]
^ abcGRCh38: Ensembl release 89: ENSG00000145777 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024379 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abEbina-Shibuya R, Leonard WJ (January 2023). "Role of thymic stromal lymphopoietin in allergy and beyond". Nature Reviews. Immunology. 23 (1): 24–37. doi:10.1038/s41577-022-00735-y. PMC 9157039. PMID 35650271.
^ abTsilingiri K, Fornasa G, Rescigno M (March 2017). "Thymic Stromal Lymphopoietin: To Cut a Long Story Short". Cellular and Molecular Gastroenterology and Hepatology. 3 (2): 174–182. doi:10.1016/j.jcmgh.2017.01.005. PMC 5331833. PMID 28275684.
^Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF (August 2016). "Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis". American Journal of Respiratory Cell and Molecular Biology. 55 (2): 264–274. doi:10.1165/rcmb.2015-0380OC. PMC 4979369. PMID 26934097.
^Corren J, Ziegler SF (December 2019). "TSLP: from allergy to cancer". Nature Immunology. 20 (12): 1603–1609. doi:10.1038/s41590-019-0524-9. PMID 31745338. S2CID 208171881.
and 28 Related for: Thymic stromal lymphopoietin information
Thymicstromallymphopoietin (TSLP) is an interleukin (IL)-2-like cytokine, alarmin, and growth factor involved in numerous physiological and pathological...
cytokines that support the TH2 profile, such as IL-33, IL-25, and thymicstromallymphopoietin, as well as the vasoactive agents calcitonin gene-related peptide...
antibody used for the treatment of asthma. Tezepelumab blocks thymicstromallymphopoietin (TSLP), an epithelial cytokine that has been suggested to be...
epithelial cells to release the inflammatory cytokines IL-33 and thymicstromallymphopoietin, which attract and activate Th2 helper T-cells. These helper...
research. IL-23 expression by dendritic cells is further induced by thymicstromallymphopoietin, a proallergic cytokine expressed by keratinocytes that is elevated...
of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) in January 2006. Sunitinib was the first cancer drug simultaneously...
through AIO-001 a long-acting monoclonal antibody that targets the thymicstromallymphopoietin cytokine. In May 2024, GSK sold off its 4.2% shares in Haleon...
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