ZINC17988990 is a drug which acts as a potent and selective inhibitor for the TRPV5 calcium channel, with an IC50 of 177 nM and high selectivity for TRPV5 over TRPV6 and the other subtypes of TRPV. It is the first selective inhibitor to be developed for TRPV5, and may be useful for modulating calcium reabsorption in the kidneys.[1]
^Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC, et al. (October 2019). "Structure-based characterization of novel TRPV5 inhibitors". eLife. 8. doi:10.7554/eLife.49572. PMC 6834369. PMID 31647410.
ZINC17988990 is a drug which acts as a potent and selective inhibitor for the TRPV5 calcium channel, with an IC50 of 177 nM and high selectivity for TRPV5...
making this a target of interest in the treatment of cancer. HC-067047 ZINC17988990 Chai H, Cheng X, Zhou B, Zhao L, Lin X, Huang D, Lu W, Lv H, Tang F,...
inhibitor of both TRPV5 and TRPV6, with an IC50 in the micromolar range ZINC17988990 is a potent and selective inhibitor of TRPV5, with an IC50 of 177nM and...