TRPC5 information

TRPC5
Identifiers
Aliases	TRPC5, PPP1R159, TRP5, transient receptor potential cation channel subfamily C member 5
External IDs	OMIM: 300334; MGI: 109524; HomoloGene: 74915; GeneCards: TRPC5; OMA:TRPC5 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	112,082,776 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	143,471,176 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; gastric mucosa; ; ganglionic eminence; ; liver; ; Brodmann area 9; ; hypothalamus; ; right lobe of liver; ; superior frontal gyrus; ; corpus callosum; ; hippocampus proper;
	Top expressed in
	supraoptic nucleus; ; lateral hypothalamus; ; ventromedial nucleus; ; superior frontal gyrus; ; secondary oocyte; ; dorsomedial hypothalamic nucleus; ; hippocampus proper; ; right ventricle; ; cerebellar cortex; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol 1,4,5 trisphosphate binding; ion channel activity; store-operated calcium channel activity; protein binding; calcium channel activity; clathrin binding; actin binding; actinin binding; ATPase binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; calcium channel complex; membrane; cytoplasm; growth cone; neuronal cell body; dendrite; membrane raft; cation channel complex;
Biological process	manganese ion transport; ion transport; regulation of cytosolic calcium ion concentration; calcium ion transmembrane transport; calcium ion transport; nervous system development; regulation of membrane hyperpolarization; positive regulation of peptidyl-threonine phosphorylation; positive regulation of axon extension; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; neuron differentiation; positive regulation of neuron differentiation; negative regulation of dendrite morphogenesis; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7224
	22067
	ENSG00000072315
	ENSMUSG00000041710
	Q9UL62
	Q9QX29
	NM_012471
	NM_009428
	NP_036603
	NP_033454
	Wikidata
View/Edit Human	View/Edit Mouse

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.^[5]^[6]^[7] TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041710 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics. 60 (3): 330–40. doi:10.1006/geno.1999.5924. PMID 10493832.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072315 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041710 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid10493832-6] Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics. 60 (3): 330–40. doi:10.1006/geno.1999.5924. PMID 10493832.

[pmid16382100-7] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

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