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TRPC4 information


TRPC4
Identifiers
AliasesTRPC4, HTRP-4, HTRP4, TRP4, transient receptor potential cation channel subfamily C member 4
External IDsOMIM: 603651; MGI: 109525; HomoloGene: 22955; GeneCards: TRPC4; OMA:TRPC4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253682
NM_001253683
NM_016984

RefSeq (protein)

NP_001240611
NP_001240612
NP_058680

Location (UCSC)Chr 13: 37.63 – 37.87 MbChr 3: 54.06 – 54.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.[5][6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133107 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027748 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L (May 1996). "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry". Cell. 85 (5): 661–71. doi:10.1016/S0092-8674(00)81233-7. PMID 8646775.
  6. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

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Family Sub-Family Known Taxa TRPC TRPC1 Vertebrates TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRP Arthropods TRPgamma TRPL Unknown Choanoflagellates, cnidarians...

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SIPA1L3 SLC9A3R1 SLC9A3R2 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 SNX27 SPAL2 STXBP4 SYNJ2BP SYNPO2 SYNPO2L TAX1BP3 TIAM1 TIAM2 TJP1 TJP2 TJP3 TRPC4 TRPC5 USH1C WHRN...

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expression pattern as TRPC4 and TRPC5. The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus...

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providing a mechanism for improving olfactory abilities. TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7 Nilius B, Owsianik G, Voets T, Peters JA (2007). "Transient...

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selective microtubule-associated protein 2 (MAP2) stimulant BI-1358894 – TRPC4 and TRPC5 inhibitor [12] Crisdesalazine (AAD-2004) – MPGES-1 inhibitor [13]...

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is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin...

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the voltage sensor domain of voltage gated ion channels. TRPC1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7 TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8...

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SNCAIP; TA-NFKBH; TEX14; TNKS; TNKS2; TNNI3K; TP53BP2; TRP7; TRPA1; TRPC3; TRPC4; TRPC5; TRPC6; TRPC7; TRPV1; TRPV2; TRPV3; TRPV4; TRPV5; TRPV6; UACA; USH1G;...

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SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5". J. Biol. Chem. 285 (16): 12426–34. doi:10.1074/jbc.M109.068304...

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pathway. RASD1 is also reported to function with leptin in the activation of TRPC4 transient receptor potential channels and, thus, plays a role in regulating...

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to interact with: AHCYL1, CA8, EPB41L1 FKBP1A, MRVI1, PRKG1, RHOA, and TRPC4. Caspr2, Inositol triphosphate Inositol triphosphate receptor GRCh38: Ensembl...

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