transcription initiation from RNA polymerase II promoter
signal transduction
steroid hormone mediated signaling pathway
positive regulation of transcription by RNA polymerase II
ovulation from ovarian follicle
epithelial cell maturation
mammary gland development
paracrine signaling
lung alveolus development
regulation of epithelial cell proliferation
progesterone receptor signaling pathway
tertiary branching involved in mammary gland duct morphogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5241
18667
Ensembl
ENSG00000082175
ENSMUSG00000031870
UniProt
P06401
Q00175
RefSeq (mRNA)
NM_000926 NM_001202474 NM_001271161 NM_001271162
NM_008829
RefSeq (protein)
NP_000917 NP_001189403 NP_001258090 NP_001258091
NP_032855
Location (UCSC)
Chr 11: 101.03 – 101.13 Mb
Chr 9: 8.9 – 8.97 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.
In humans, PR is encoded by a single PGR gene residing on chromosome 11q22,[5][6][7] it has two isoforms, PR-A and PR-B, that differ in their molecular weight.[8][9][10] The PR-B is the positive regulator of the effects of progesterone, while PR-A serve to antagonize the effects of PR-B.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000082175 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031870 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (March 1987). "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research Communications. 143 (2): 740–8. doi:10.1016/0006-291X(87)91416-1. PMID 3551956.
^Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (May 1987). "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2877–81. Bibcode:1987PNAS...84.2877L. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.
^ensembl.org, Gene: ESR1 (ENSG00000091831)
^Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C (2005). "Progesterone receptors: various forms and functions in reproductive tissues". Frontiers in Bioscience. 10 (1–3): 2118–30. doi:10.2741/1685. PMID 15970482.
^Kase NG, Speroff L, Glass RL (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-683-30379-7.
^Fritz MA, Speroff L (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4795-0.
^Falcone T, Hurd WW (22 May 2013). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. pp. 39–. ISBN 978-1-4614-6837-0.
and 26 Related for: Progesterone receptor information
The progesteronereceptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated...
prescribed in 1934. Progesterone is the most important progestogen in the body. As a potent agonist of the nuclear progesteronereceptor (nPR) (with an affinity...
drugs competitively inhibit progestin at progesteronereceptors. They act by blocking the progesteronereceptor (PR)and/or inhibiting or suppressing progestogen...
A selective progesteronereceptor modulator (SPRM) is an agent that acts on the progesteronereceptor (PR), the biological target of progestogens like...
The progesteronereceptor A (PR-A) is one of three known isoforms of the progesteronereceptor (PR), the main biological target of the endogenous progestogen...
Membrane progesteronereceptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR)...
synthetic steroid hormones that bind to and activate the progesteronereceptors (PR). Progesterone is the major and most important progestogen in the body...
progestogen, and hence is an agonist of the progesteronereceptor, the biological target of progestogens like progesterone. The medication is an atypical progestogen...
or an agonist of the progesteronereceptor, the biological target of progestogens like endogenous progesterone. Progesterone also has antimineralocorticoid...
National Laboratory, whose work in isolating and characterizing the progesteronereceptor gene stimulated advances in breast biology and oncology. She was...
of administration. Progesterone is a naturally occurring and bioidentical progestogen, or an agonist of the progesteronereceptor, the biological target...
The progesteronereceptor C (PR-C) is one of three known isoforms of the progesteronereceptor (PR), the main biological target of the endogenous progestogen...
(September 2006). "Determination of conformational changes in the progesteronereceptor using ELISA-like assays". Steroids. 71 (9): 792–8. doi:10.1016/j...
The progesteronereceptor B (PR-B) is one of three known isoforms of the progesteronereceptor (PR), the main biological target of the endogenous progestogen...
progestogen, and hence is an agonist of the progesteronereceptor, the biological target of progestogens like progesterone. It has weak androgenic and estrogenic...
androgen receptor (AR), moderate affinity for the progesteronereceptor (PR) and glucocorticoid receptor (GR), and poor affinity for the estrogen receptor (ER)...
kainate, and glycine receptors. Unlike progesterone, allopregnanolone is inactive at the classical nuclear progesteronereceptor (PR). However, allopregnanolone...
progestogen, and hence is an agonist of the progesteronereceptor, the biological target of progestogens like progesterone. It has very weak androgenic and glucocorticoid...
trenbolone acetate and its compounds bind with high affinity to the progesteronereceptor. It has been assumed that gynecomastia as a result of trenbolone...
progestogen, and hence is an agonist of the progesteronereceptor, the biological target of progestogens like progesterone. It has some antimineralocorticoid activity...
nuclear receptors include members of subfamily 3, such as the androgen receptor, estrogen receptors, glucocorticoid receptor, and progesteronereceptor. It...
progestogen, and hence is an agonist of the progesteronereceptor, the biological target of progestogens like progesterone. It has additional antimineralocorticoid...
progestogen, and hence is an agonist of the progesteronereceptor, the biological target of progestogens like progesterone. It is a unique progestogen, with strong...
Progesteronereceptor membrane component 1 (abbreviated PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary...
binding. As hormone receptors for sex steroids (steroid hormone receptors), ERs, androgen receptors (ARs), and progesteronereceptors (PRs) are important...
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