TFAP2A information

TFAP2A
Identifiers
Aliases	TFAP2A, AP-2, AP-2alpha, AP2TF, BOFS, TFAP2, transcription factor AP-2 alpha
External IDs	OMIM: 107580; MGI: 104671; HomoloGene: 2421; GeneCards: TFAP2A; OMA:TFAP2A - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	10,419,659 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	40,891,852 bp
RNA expression pattern
	Top expressed in
	vulva; ; skin of abdomen; ; hair follicle; ; lactiferous duct; ; nipple; ; placenta; ; human penis; ; palpebral conjunctiva; ; corpus epididymis; ; minor salivary glands;
	Top expressed in
	hair follicle; ; conjunctival fornix; ; lip; ; cornea; ; skin of abdomen; ; parotid gland; ; maxillary prominence; ; skin of back; ; corneal stroma; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II core promoter sequence-specific DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	centrosome; Golgi apparatus; intracellular membrane-bounded organelle; nucleus; nucleoplasm; cytosol;
Biological process	roof of mouth development; cellular response to iron ion; regulation of transcription, DNA-templated; retina layer formation; kidney development; positive regulation of bone mineralization; trigeminal nerve development; negative regulation of transcription by competitive promoter binding; optic vesicle morphogenesis; bone morphogenesis; negative regulation of apoptotic process; hearing; eyelid development in camera-type eye; transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of neuron apoptotic process; positive regulation of gene expression; inner ear morphogenesis; optic cup structural organization; regulation of cell differentiation; embryonic cranial skeleton morphogenesis; negative regulation of reactive oxygen species metabolic process; negative regulation of transcription, DNA-templated; embryonic forelimb morphogenesis; oculomotor nerve formation; negative regulation of cell population proliferation; positive regulation of tooth mineralization; transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	7020
	21418
	ENSG00000137203
	ENSMUSG00000021359
	P05549
	P34056
	NM_001032280; NM_001042425; NM_003220; NM_001372066
	NM_001122948; NM_001301674; NM_011547
	NP_001027451; NP_001035890; NP_003211; NP_001358995
	NP_001116420; NP_001288603; NP_035677
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in humans is encoded by the TFAP2A gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137203 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021359 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137203 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021359 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)".

TFAP2A information

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