IRF4 information

IRF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DLL
Identifiers
Aliases	IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4
External IDs	OMIM: 601900; MGI: 1096873; HomoloGene: 1842; GeneCards: IRF4; OMA:IRF4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	411,443 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	30,950,959 bp
RNA expression pattern
	Top expressed in
	lymph node; ; canal of the cervix; ; appendix; ; bone marrow cells; ; cartilage tissue; ; spleen; ; epithelium of colon; ; ectocervix; ; rectum; ; superficial temporal artery;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; blood; ; subcutaneous adipose tissue; ; granulocyte; ; brown adipose tissue; ; mammary gland; ; submandibular gland; ; bone marrow; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein-lysine N-methyltransferase activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytosol; membrane; nucleoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; interferon-gamma-mediated signaling pathway; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; transcription, DNA-templated; T-helper 17 cell lineage commitment; positive regulation of transcription, DNA-templated; peptidyl-lysine methylation; negative regulation of toll-like receptor signaling pathway; type I interferon signaling pathway; histone H3 acetylation; histone H4 acetylation; positive regulation of DNA binding; T cell activation; positive regulation of transcription by RNA polymerase II; defense response to protozoan; protein methylation; transcription by RNA polymerase II; cytokine-mediated signaling pathway; positive regulation of cold-induced thermogenesis; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	3662
	16364
	ENSG00000137265
	ENSMUSG00000021356
	Q15306
	Q64287
	NM_001195286; NM_002460
	NM_013674; NM_001347508
	NP_001182215; NP_002451
	NP_001334437; NP_038702
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene.^[5]^[6]^[7] IRF4 functions as a key regulatory transcription factor in the development of human immune cells.^[8]^[9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells.^[8] Dysregulation of the IRF4 gene can result in IRF4 functioning either as an oncogene or a tumor-suppressor, depending on the context of the modification.^[8]

The MUM1 symbol is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137265 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021356 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grossman A, Mittrücker HW, Nicholl J, Suzuki A, Chung S, Antonio L, et al. (October 1996). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics. 37 (2): 229–233. doi:10.1006/geno.1996.0547. PMID 8921401. S2CID 42646350.
^ Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (July 2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". Journal of Virology. 82 (13): 6251–6258. doi:10.1128/JVI.00163-08. PMC 2447047. PMID 18417578.
^ "Entrez Gene: IRF4 interferon regulatory factor 4".
^ ^a ^b ^c Nam S, Lim J-S (2016). "Essential role of interferon regulatory factor 4 (IRF4) in immune cell development." Arch. Pharm. Res. 39: 1548–1555. doi:10.1007/s12272-016-0854-1.
^ Shaffer AL, Tolga Emre NC, Romesser PB, Staudt LM (2009). "IRF4: Immunity. Malignancy! Therapy?" Clinical Cancer Research. 15 (9): 2954-2961. doi:10.1158/1078-0432.CCR-08-1845

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137265 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021356 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8921401-5] Grossman A, Mittrücker HW, Nicholl J, Suzuki A, Chung S, Antonio L, et al. (October 1996). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics. 37 (2): 229–233. doi:10.1006/geno.1996.0547. PMID 8921401. S2CID 42646350.

[pmid18417578-6] Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (July 2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". Journal of Virology. 82 (13): 6251–6258. doi:10.1128/JVI.00163-08. PMC 2447047. PMID 18417578.

[entrez-7] "Entrez Gene: IRF4 interferon regulatory factor 4".

[:0-8] Nam S, Lim J-S (2016). "Essential role of interferon regulatory factor 4 (IRF4) in immune cell development." Arch. Pharm. Res. 39: 1548–1555. doi:10.1007/s12272-016-0854-1.

[:1-9] Shaffer AL, Tolga Emre NC, Romesser PB, Staudt LM (2009). "IRF4: Immunity. Malignancy! Therapy?" Clinical Cancer Research. 15 (9): 2954-2961. doi:10.1158/1078-0432.CCR-08-1845

IRF4 information

and 26 Related for: IRF4 information

IRF4

Iridium tetrafluoride

Interferon regulatory factors

Germinal center

Lenalidomide

T cell

Iridium

Greying of hair

Uranium hexafluoride

List of CAS numbers by chemical compound

Tumors of the hematopoietic and lymphoid tissues

Magnesium fluoride

Potassium fluoride

Hydrogen fluoride

Sodium fluoride

Plasma cell

Oxygen difluoride

Calcium fluoride

Dioxygen difluoride

Osmium heptafluoride

Lithium fluoride

Follicular lymphoma

Antimony pentafluoride

Tungsten hexafluoride

Halogen

List of human transcription factors