In molecular biology, a GC box, also known as a GSG box,[1] is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes. The GC box is upstream of the TATA box, and approximately 110 bases upstream from the transcription initiation site. It has a consensus sequence GGGCGG which is position-dependent and orientation-independent. The GC elements are bound by transcription factors and have similar functions to enhancers.[2] Some known GC box-binding proteins include Sp1, Krox/Egr, Wilms' tumor, MIGI, and CREA.[1]
The GC box is commonly the binding site for zinc finger proteins. An alpha helix section of the protein corresponds with a major groove in the DNA. Zinc-fingers bind to triplet base pair sequences, with residue 21 binding to the first base pair, residue 18 binding to the second base pair, and residue 15 binding to the third base pair. The triplet base pairs can either be a GGG or a GCG. If residue 18 is a histidine, it will bind to a G, and if residue 18 is a glutamate, it will bind to a C. GC box-binding zinc fingers have between 2 and 4 fingers, making them interact with base pair sequences that are 6 to 8 base pairs in length.[1]
^ abcLundin, M.; Nehlin, J. O.; Ronne, H. (1994-03-01). "Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1". Molecular and Cellular Biology. 14 (3): 1979–1985. doi:10.1128/MCB.14.3.1979. ISSN 0270-7306. PMC 358557. PMID 8114729.
^Klug WS, Cummings MR, Spencer CA, Palladina MA (2009). Concepts of Genetics (Ninth ed.). San Francisco: Pearson Benjamin Cummings. pp. 463–464. ISBN 978-0-321-54098-0.
biology, a GCbox, also known as a GSG box, is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes. The GCbox is upstream...
genes that encode proteins used in virtually all cells. This box along with the GCbox is known for binding general transcription factors. Both of these...
'Black Box' Label On Heart Risks". The Wall Street Journal. Retrieved January 2, 2024. Dorsey ER, Rabbani A, Gallagher SA, Conti RM, Alexander GC (January...
The TATA box is located approximately 20 base-pairs upstream from the transcriptional start site. The 21 base-pair repeats contain six GCboxes and are...
varying lengths. Zinc fingers often bind to a sequence of DNA known as the GCbox. The modular nature of the zinc finger motif allows for a large number of...
Compiled by RPM magazine. Copies are missing from the collectionscanada.gc.ca archive meaning some chart peaks could be inaccurate. "Discografie von...
transcription factor that binds to GCbox elements located in the promoter. Binding of the encoded protein to a single GCbox inhibits mRNA expression while...
and can be used in such things as floor boards, and door construction. Dovetail joint Miter joint Box joint Lap joint https://www.nrcan.gc.ca/forests...
can be an activator or a repressor. In the SV40 virus, Sp1 binds to the GCboxes in the regulatory sequence of the genome. SP1 belongs to the Sp/KLF family...
binding domains in its structure to bind directly to a GC-rich region of the genome known as the GCbox. creating downstream regulatory effects. There are...
.. "Item Display – RPM – Library and Archives Canada". Collectionscanada.gc.ca. Archived from the original on October 15, 2012. Retrieved February 22...
January 19 1974". collectionscanada.gc.ca. Archived from the original on October 21, 2012. Retrieved April 30, 2018. "Cash Box YE Pop Singles - 1974". www.cashboxmagazine...
the ATA box". Biochemical and Biophysical Research Communications. 153 (2): 741–7. doi:10.1016/S0006-291X(88)81157-4. PMID 3382401. Bower GC (1978). "The...
Global Information