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An immunoproteasome is a type of proteasome that degrades ubiquitin-labeled proteins found in the cytoplasm in cells exposed to oxidative stress and proinflammatory stimuli. In general, proteasomes consist of a regulatory and a catalytic part. Immunoproteasomes are induced by interferon gamma (but also by other proinflammatory cytokines) and oxidative stress, which in the cell triggers the transcription of three catalytic subunits that do not occur in the classical proteasome.[1] Another possible variation of proteasome is the thymoproteasome, which is located in the thymus and folds to present peptides to naive T cells.
^Ferrington DA, Gregerson DS (2012). "Immunoproteasomes: structure, function, and antigen presentation". Progress in Molecular Biology and Translational Science. 109. Elsevier: 75–112. doi:10.1016/b978-0-12-397863-9.00003-1. ISBN 978-0-12-397863-9. PMC 4405001. PMID 22727420.
An immunoproteasome is a type of proteasome that degrades ubiquitin-labeled proteins found in the cytoplasm in cells exposed to oxidative stress and proinflammatory...
But in thymus we can also find another type of specific proteasome, immunoproteasome, which is present in thymocytes, dendritic cells and medular thymic...
chymotrypsin-like activity of both the constitutive proteasome (PSMB5) and immunoproteasome (LMP7). It is being investigated for the treatment of hematologic malignancies...
This protein has a major role in the immune system as part of an immunoproteasome that is primarily induced upon infection and formed by replacing constitutive...
histocompatibility complex molecules, MHC I and MHC II, and increase immunoproteasome activity. All interferons significantly enhance the presentation of...
proteasome assembled with these alternative subunits is known as the immunoproteasome, whose substrate specificity is altered relative to the normal proteasome...
complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous...
biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The human PSMB7 gene has...
through induction of antigen processing genes, including subunits of the immunoproteasome (MECL1, LMP2, LMP7), as well as TAP and ERAAP in addition possibly...
biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The human gene contains...
complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous...
biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The gene PSMB5 encodes...
ubiquitination of certain histones, and blocking peptide degradation by the immunoproteasome, E1A is able to reduce antigen presentation on adenovirus-infected...
histocompatibility complex molecules, MHC I and MHC II, and stimulate immunoproteasome activity. All interferons drastically increase the presentation of...
Fam158a. PSME1 is a subunit of the 11S regulator which is a part of the immunoproteasome responsible for cleaving MHC class I peptides. PSME2 is another subunit...
was recently described that interferon-α-mediated stimulation of the immunoproteasome enables human TRIM5α for effective capsid-dependent inhibition of HIV-1...
non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The gene PSMD7 encodes...
function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred...
"Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells". Immunity. 12 (1):...
biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene PSMB4 encodes...
function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred...
non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein...
function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred...
biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The gene PSMB1 encodes...
non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of...
Addey C, Scott D, Dyson J, Simpson E, Cerundolo V. 2006. Role of Immunoproteasomes in cross-presentation. J Immunol, 177: 983-990. Chen, J.-L., G. Stewart-Jones...
Lin G (April 2014). "Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome". ACS Medicinal Chemistry Letters...
biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The gene PSMB2 encodes...
non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase...
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