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T helper cell 22, also known as the Th22 cell, are a type of immune cell. Th22 are a derivative of naïve CD4+ T cells induced by the ligand activation of the transcription factor aryl hydrocarbon receptor (AhR),[1] which uses environmental, metabolic, microbial, and dietary cues to control complex transcriptional programmes.[2] Th22 cell’s function is mediated by its ligand specific cytokine interleukin-22 (IL-22).[3]
^Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H (August 2009). "Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells". Nature Immunology. 10 (8): 864–871. doi:10.1038/ni.1770. PMID 19578368. S2CID 30507460.
^Rothhammer V, Quintana FJ (March 2019). "The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease". Nature Reviews. Immunology. 19 (3): 184–197. doi:10.1038/s41577-019-0125-8. PMID 30718831. S2CID 59603271.
^Jia L, Wu C (2014). "The Biology and Functions of Th22 Cells". In Sun B (ed.). T Helper Cell Differentiation and Their Function. Advances in Experimental Medicine and Biology. Vol. 841. Dordrecht: Springer Netherlands. pp. 209–230. doi:10.1007/978-94-017-9487-9_8. ISBN 978-94-017-9487-9. PMID 25261209.
CD4+ "helper" Tcells. (These are named for the presence of the cell surface proteins CD8 or CD4.) CD8+ Tcells, also known as "killer Tcells", are cytotoxic...
regulatory Tcells). These Treg cells are different from helperTcells. Another regulatory Tcell subset is Treg17 cells. Regulatory Tcells are involved...
immunoreceptors, chimeric Tcell receptors or artificial Tcell receptors—are receptor proteins that have been engineered to give Tcells the new ability to...
cytotoxic Tcells (CD8-positive) subset, similar populations appear to exist for both the helperTcells (CD4-positive) and the cytotoxic Tcells. Primary...
Gamma delta Tcells (γδ Tcells) are Tcells that have a γδ T-cell receptor (TCR) on their surface. Most Tcells are αβ (alpha beta) Tcells with TCR composed...
for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helperTcells, monocytes, macrophages, and dendritic cells. It was...
Tcell deficiency is a deficiency of Tcells, caused by decreased function of individual Tcells, it causes an immunodeficiency of cell-mediated immunity...
yet. This process occurs during follicular helperTcell formation in lymph node germinal centers. Tcell revision is achieved via reactivation of recombination...
CD8+ Tcells, the formation of CD8+ memory Tcells requires the interaction of dendritic cells with CD4+ helperTcells. This help from CD4+ Tcells additionally...
Th22 cells (Thelpercells type 22) are subpopulation of CD4+ Tcells that produce interleukin-22 (IL-22). They play a role in the protective mechanisms...
HIV infects vital cells in the human immune system, such as helperTcells (specifically CD4+ Tcells), macrophages, and dendritic cells. HIV infection leads...
The replicon containing the vir genes became known as the vir helper plasmid. The vir helper plasmid is considered disarmed if it does not contain oncogenes...
person, these activated cells present the antigen to the effector lymphocytes (CD4+ helperTcells, cytotoxic CD8+ Tcells and B cells). This initiates a cytotoxic...
that induces differentiation of naive helperTcells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4...
CD4 helperT-lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and...
cytotoxic and CD4+ helperTcell populations that are vital in combating the virus. Immune blockade of PD-1 resulted in restoration of Tcell inflammatory phenotype...
(B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. BCL6 is a master transcription factor for regulation of T follicular helper...
Pai SY (February 2009). "GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation". Nature Reviews Immunology...
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