Synthetic antibodies are affinity reagents generated entirely in vitro, thus completely eliminating animals from the production process.[1] Synthetic antibodies include recombinant antibodies, nucleic acid aptamers and non-immunoglobulin protein scaffolds. As a consequence of their in vitro manufacturing method the antigen recognition site of synthetic antibodies can be engineered to any desired target and may extend beyond the typical immune repertoire offered by natural antibodies.[2] Synthetic antibodies are being developed for use in research, diagnostic and therapeutic applications. Synthetic antibodies can be used in all applications where traditional monoclonal or polyclonal antibodies are used and offer many inherent advantages over animal-derived antibodies, including comparatively low production costs, reagent reproducibility and increased affinity, specificity and stability across a range of experimental conditions.[3]
^Echko, M.M. and Dozier, S.K. (2010). "Recombinant antibody technology for the production of antibodies without the use of animals". AltTox.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Bradbury, A.R.M., Sidhu, S., Dübel, S. and McCafferty, J (2011). "Beyond natural antibodies: The power of in vitro display technologies". Nat. Biotechnol. 29 (3): 245–254. doi:10.1038/nbt.1791. PMC 3057417. PMID 21390033.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Gebauer, M. and Skerra (June 2009). "Engineered protein scaffolds as next-generation antibody therapeutics". Curr Opin Chem Biol. 13 (3): 245–55. doi:10.1016/j.cbpa.2009.04.627. PMID 19501012.
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