Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent.[1] It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody.[2]
^Tai, Y. T.; Mayes, P. A.; Acharya, C; Zhong, M. Y.; Cea, M; Cagnetta, A; Craigen, J; Yates, J; Gliddon, L; Fieles, W; Hoang, B; Tunstead, J; Christie, A. L.; Kung, A. L.; Richardson, P; Munshi, N. C.; Anderson, K. C. (2014). "Novel afucosylated anti-B cell maturation antigen-monomethyl auristatin F antibody-drug conjugate (GSK2857916) induces potent and selective anti-multiple myeloma activity". Blood. 123 (20): 3128–38. doi:10.1182/blood-2013-10-535088. PMC 4023420. PMID 24569262.
^Statement on a nonproprietary name adopted by the USAN Council: Mafodotin
and 15 Related for: Monomethyl auristatin F information
Monomethylauristatin is any of a group of synthetic antineoplastic agents derived from the sea slug Dolabella auricularia: Monomethylauristatin E Monomethyl...
Monomethylauristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked...
antigen (BCMA) conjugated with a cytotoxic agent, maleimidocaproyl monomethylauristatinF (mcMMAF). The antibody-drug conjugate binds to BCMA on myeloma...
monoclonal antibody, vorsetuzumab, conjugated with noncleavable monomethylauristatinF (MMAF), a cytotoxic agent.[citation needed] This drug was developed...
monoclonal antibody (depatuxizumab) conjugated to the tubulin inhibitor monomethylauristatinF via a stable maleimidocaproyl link. This drug was developed by...
non-Hodgkin lymphoma. It consists of an anti-CD19 mAb linked to monomethylauristatinF (MMAF), a cytotoxic agent. This drug was developed by Seattle Genetics...
called in the Philippines Lukot or Lokot. The anti-cancer agent monomethylauristatin E is derived from peptides found in D. auricularia. In Samoa it...
drug targeting purposes. The word vedotin, for example, stands for monomethylauristatin E which is toxic by itself but predominantly affects cancer cells...
Trabectedin, aplidine, didemnin, were isolated from sea squirts. Monomethylauristatin E is a derivative of a dolastatin 10, a compound made by Dolabella...
antibody recognizing extracellular ROR1, a cleavable linker and monomethylauristatin E has entered clinical trials for the treatment of lymphoid malignancies...
conjugate (ADC) 0BI-999 was additionally developed, linking OBI-888 to monomethylauristatin E, a synthetic antineoplastic agent. The ADC is currently undergoing...
and is constructed by chimeric anit-CD30 IgG1 antibody (cAC10), monomethylauristatin E (MMAE, a potent cytotoxic drug) and a linker that attaches MMAE...